2026-05-28T08:51:49Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/394312026-02-03T11:07:40Zcom_10630_2254col_10630_37953

Cellular recovery and body composition changes in pediatric celiac disease after the start of a gluten-free diet: a prospective cohort study Nestares, Teresa Jiménez Muñoz, María Torcuato-Rubio, Encarnación Tamayo Pérez, Laura De La Flor Alemany, Marta Herrador-López, Marta Navas-López, Víctor Manuel Martin‐Masot, Rafael Enfermedad celíaca en niños Dietas sin gluten Cuerpo humano - Composición This study was funded by the Regional Government of Andalusia, Excellence Research Project No P21_00101. Background/Objectives: Celiac disease (CD) alters nutrient absorption and body composi- tion, especially during childhood. Although adherence to a gluten-free diet (GFD) promotes mucosal recovery, its impact on cellular functionality and metabolic balance remains under- explored. This study aims to evaluate the utility of bioelectrical impedance vector analysis (BIVA) in assessing nutritional status, inflammatory improvement, and body composition changes in pediatric patients with CD following a GFD. Methods: Seventy-nine children aged 5–14 years were studied. Three groups were analyzed: (1) 25 children with newly diagnosed CD, evaluated at diagnosis and after 12 months of GFD (prospective cohort); (2) 25 CD patients on a GFD for over 24 months (cross-sectional); and (3) 29 healthy controls. Body composition (fat mass (FM), fat-free mass (FFM), body cell mass (BCM), phase angle (PhA), and Na+/K+ ratio) was measured. GFD adherence was assessed and a dietary assessment was also performed. Results: After 12 months on a GFD, newly diagnosed CD patients showed significant increases in FM (from 8.2 to 10.1 kg, p = 0.001), FFM (p = 0.001), and BCM (p = 0.0001), along with a significant decrease in the Na+/K+ ratio (p = 0.015). Compared to healthy controls, CD children on GFD for more than 24 months had higher FM (12.2 vs. 8.8 kg, p = 0.013) and lower Na+/K+ ratios (p = 0.006). PhA increased slightly over time but did not reach statistical significance. Conclusions: Our study suggests that the adherence to a GFD leads to improved body composition and cellular homeostasis in children with CD, as reflected by increases in BCM and reductions in Na+/K+ ratio, making it a promising biomarker for monitoring inflammation and cellular recovery. 2025-07-21T12:02:42Z 2025-07-21T12:02:42Z 2025 journal article Nestares T, Jiménez-Muñoz M, Torcuato-Rubio E, Tamayo Pérez L, de la Flor Alemany M, Herrador-López M, Navas-López V, Martín-Masot R. Cellular Recovery and Body Composition Changes in Pediatric Celiac Disease After the Start of a Gluten-Free Diet: A Prospective Cohort Study. Journal of Clinical Medicine. 2025; 14(14):5061. https://hdl.handle.net/10630/39431 10.3390/jcm14145061 eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 Internacional MDPI