2026-05-28T08:05:50Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/401032026-02-03T11:00:23Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Abdi, Khadar author Lai, Chun-Hsiang author Páez-González, Patricia author Lay, Mark author Pyun, Joon author Kuo, Chay T. author 2018-04-25 Specialized, differentiated cells often perform unique tasks that require them to maintain a stable phenotype. Multiciliated ependymal cells (ECs) are unique glial cells lining the brain ventricles, important for cerebral spinal fluid circulation. While functional ECs are needed to prevent hydrocephalus, they have also been reported to generate new neurons: whether ECs represent a stable cellular population remains unclear. Via a chemical screen we found that mature ECs are inherently plastic, with their multiciliated state needing constant maintenance by the Foxj1 transcription factor, which paradoxically is rapidly turned over by the ubiquitin-proteasome system leading to cellular de-differentiation. Mechanistic analyses revealed a novel NF-κB-independent IKK2 activity stabilizing Foxj1 in mature ECs, and we found that known IKK2 inhibitors including viruses and growth factors robustly induced Foxj1 degradation, EC de-differentiation, and hydrocephalus. Although mature ECs upon de-differentiation can divide and regenerate multiciliated ECs, we did not detect evidence supporting EC's neurogenic potential. Abdi K, Lai CH, Paez-Gonzalez P, Lay M, Pyun J, Kuo CT. Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun. 2018 Apr 25;9(1):1655. doi: 10.1038/s41467-018-03812-w. PMID: 29695808; PMCID: PMC5916891. https://hdl.handle.net/10630/40103 10.1038/s41467-018-03812-w Epéndimo Cilios Hidrocefalia Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus.