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Aledo-Ramos, Juan Carlos 2025-10-09T12:08:58Z 2025-10-09T12:08:58Z 2021-05-08 Juan Carlos Aledo, ptm: an R package for the study of methionine sulfoxidation and other posttranslational modifications, Bioinformatics, Volume 37, Issue 21, November 2021, Pages 3979–3980, https://doi.org/10.1093/bioinformatics/btab348 https://hdl.handle.net/10630/40158 10.1093/bioinformatics/btab348 Summary: Methionine sulfoxidation is a posttranslational modification (PTM) playing important roles in cell signal- ing. Herein, we present ptm, an R package for the study of this modification. However, since many of the analyses applied to methionine modification can be extended to other modifications, the package can be useful to thoroughly analyze PTMs in general. Thus, within a single software environment, ptm can integrate information from up to 11 databases covering nine modifications. Different functions can work coordinately to form pipelines allowing the pro- grammatic analysis of thousands of proteins. Alternatively, the user can simultaneously perform different analyses on the same protein of interest, combining the results into a single output. The flexibility of ptm makes it a suitable tool to address site- and protein-centric hypotheses related to PTMs. Accompanying the package, we maintain a web page containing extended documentation and examples of the tasks that can be performed with ptm. Availability and implementation: ptm is implemented in R. Release versions are available via CRAN and work on all major operating systems. The development version is maintained at https://bitbucket.org/jcaledo/ptm. Extended documentation can be found at https://metositeptm.com eng open access Bioinformática Metionina Modificación postraslacional ptm: an R package for the study of methionine sulfoxidation and other posttranslational modifications. journal article