2026-06-01T19:52:00Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/402032026-02-03T12:08:14Zcom_10630_2254col_10630_37959

Differential Impacts of Acute, Chronic, and Social Defeat Stress on Microglial Morphology in the Amygdala and Habenula Zea-Doña, Alejandro Nieto-Quero, Andrea Infantes-López, M. Inmaculada Arjona, A. Tabbai-Amal, Sara Zambrana-Infantes, Emma Chaves-Peña, Patricia Muñoz-Martín, José Martín-Aguiar, Víctor Blanca-Mena, María José Pérez-Martín, Margarita Pedraza-Benítez, María del Carmen Microglia Núcleo amigdalino Neuropsiquiatría Estrés (Fisiología) Stress is a major risk factor for neuropsychiatric disorders, including depression and post-traumatic stress disorder (PTSD), which disrupt emotional regulation and cognitive function. Microglia, the brain’s resident immune cells, play a critical role in maintaining neural homeostasis by modulating synaptic plasticity and responding to environmental challenges. Their morphological changes, such as alterations in soma size, density, and circularity, reflect distinct neuroimmune responses to stress. This study focuses on the basolateral (BLA) and central (CeA) amygdala, key for emotional processing, and the lateral (LHb) and medial (MHb) habenula, involved in motivation and reward. Understanding region-specific microglial adaptations to acute, chronic, and social defeat stress may help uncover mechanisms underlying stress vulnerability. 2025-10-14T08:53:13Z 2025-10-14T08:53:13Z 2025 conference output https://hdl.handle.net/10630/40203 eng 20th Meeting of the Spanish Society for Neuroscience Las Palmas de Gran Canaria, España 3-5 de septiembre de 2025 info:eu-repo/grantAgreement/AEI//PID2020-117464RBI00/ES// info:eu-repo/grantAgreement/MICIU-AEI//PID2023-151537OB-I00/ES// info:eu-repo/grantAgreement/JuntaDeAndalucía/ConsejeríaDeConocimientoInvestigaciónYUniversidades/P20_00460/ES// open access