2026-05-29T23:15:23Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/402052026-02-03T11:13:44Zcom_10630_2254col_10630_37953

Automated detection of speech timing alterations in autopsy-confirmed non-fluent/agrammatic variant primary progressive aphasia García, Adolfo M. Welch, Ariane E. Mandelli, Maria Luisa Henry, Maya L. Lukic, Sladjana Torres-Prioris, María José Deleon, Jessica Ratnasiri, Buddhika M. Lorca Puls, Diego L. Miller, Bruce L. Seeley, William W. Vogel, Adam P. Gorno-Tempini, Maria Luisa Afasia Background and objectives: Motor speech function, including speech timing, is a key domain for diagnosing nonfluent/agrammatic variant primary progressive aphasia (nfvPPA). Yet, standard assessments use subjective, specialist-dependent evaluations, undermining reliability and scalability. Moreover, few studies have examined relevant anatomo-clinical alterations in patients with pathologically confirmed diagnoses. This study overcomes such caveats using automated speech timing analyses in a unique cohort of autopsy-proven cases. 2025-10-14T09:06:54Z 2025-10-14T09:06:54Z 2022 journal article García, A. M., Welch, A. E., Mandelli, M. L., Henry, M. L., Lukic, S., Torres Prioris, M. J., Deleon, J., Ratnasiri, B. M., Lorca-Puls, D. L., Miller, B. L., Seeley, W., Vogel, A. P., & Gorno-Tempini, M. L. (2022). Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia. Neurology, 99(5), e500–e511. https://doi.org/10.1212/WNL.0000000000200750 https://hdl.handle.net/10630/40205 10.1212/wnl.0000000000200750 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Lippincott, Williams & Wilkins