2026-05-28T08:53:56Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/402852026-02-03T11:05:51Zcom_10630_2254col_10630_37953

Systematic review: ibuprofen-induced liver injury. Zoubek, Miguel E. Lucena-González, María Isabel Andrade-Bellido, Raúl Jesús Stephens, Camilla Hepatotoxicidad Hígado - Heridas y lesiones Ibuprofeno - Efectos secundarios Revisiones sistemáticas (Medicina) Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause of drug-induced liver injury (DILI) across the world. Ibuprofen is one of the most commonly used and safest NSAIDs, nevertheless reports on ibuprofen-induced hepatotoxicity are available. Aim: To analyse previously published information on ibuprofen-induced liver injury for a better characterisation of its phenotypic expression. Method: A systematic search was performed and information on ibuprofen-induced liver injury included in case series and case reports, in terms of demographic, clinical, biochemical and outcome data, was analysed. Results: Twenty-two idiosyncratic ibuprofen hepatotoxicity cases were identified in the literature, suggesting a very low prevalence of this type of DILI. These patients had a mean age of 31 years and 55% were females. Mean cumulative dose of ibuprofen and time to onset were 30 g and 12 days, respectively. Hepatocellular injury was the most frequently involved liver injury pattern. Six cases developed vanishing bile duct syndrome. Full recovery occurred in 11 patients after a mean time of 14 weeks, whereas five cases evolved to acute liver failure leading to death/liver transplantation. Conclusions: When assessing potential hepatotoxicity cases, physicians should keep in mind that ibuprofen has been associated with hepatotoxicity in the literature. Ibuprofenassociated DILI presents commonly as hepatocellular damage after a short latency period. Published reports on ibuprofen hepatotoxicity leading to liver failure resulting in liver transplantation or death are available. However, due to the apparent low absolute risk of ibuprofen-induced liver complications, ibuprofen can be regarded as an efficacious and safe NSAID. 2025-10-17T07:10:36Z 2025-10-17T07:10:36Z 2025-10-17T07:10:36Z 2020-01-27 journal article Miguel E Zoubek, María Isabel Lucena, Raúl J Andrade, Camilla Stephens. Systematic review: ibuprofen-induced liver injury. Aliment Pharmacol Ther 2020 Mar;51(6):603-611 https://hdl.handle.net/10630/40285 10.1111/apt.15645 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley-Blackwell