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High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries. Zoubek, Miguel E. González-Jiménez, Andrés Medina-Cáliz, Inmaculada Robles-Díaz, María Mercedes Hernandez, Nelia Romero-Gomez, Manuel Bessone, Fernando Hallal, Hacibe Cubero, Francisco Javier Lucena-González, María Isabel Stephens, Camilla Andrade-Bellido, Raúl Jesús Hepatotoxicidad Hígado - Lesiones y heridas Ibuprofeno - Efectos secundarios https://openpolicyfinder.jisc.ac.uk/id/publication/4740 Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 3% to 10% of idiosyncratic drug-induced liver injury (DILI) cases in the Western world.1–3 Ibuprofen is a widely prescribed NSAID avail- able as over-the-counter medication (OTC), and perceived as having a better safety profile than many other NSAIDs. Interestingly, striking regional differences in the frequency of ibuprofen hepatotoxicity were noted in a comparison of causative DILI agents among large DILI cohorts in 2010.4 Based on the limited information available on this type of DILI, we aimed to analyze the clinical presentation of ibuprofen-associated hepatotox- icity in the search for a potential drug signature. 2025-10-17T07:27:47Z 2025-10-17T07:27:47Z 2018-02 journal article Zoubek ME, González-Jimenez A, Medina-Cáliz I, Mercedes Robles-Díaz, Hernandez N, Romero-Gómez R, Bessone F, Hallal H, Cubero FJ, Lucena MI, Stephens C, Andrade RJ. High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries. Clin Gastroenterol Hepatol 2018 Feb;16(2):292-294 https://hdl.handle.net/10630/40286 10.1016/j.cgh.2017.07.037 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier