2026-06-06T02:15:48Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/403852026-02-03T11:33:35Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Rivera-González, Patricia author Martos-Moreno, Gabriel author Barrios, Vicente author Suárez-Pérez, Juan author Pavón, Francisco javier author Chowen, Julie A author Rodriguez de Fonseca, Fernando author Argente, Jesús author 2021 Background: In obesity adipose tissue undergoes structural re-modelling leading to a chronic low-grade inflammatory state linked to insulin resistance (IR). Objective: We aimed to develop a clinically relevant biomarker model for stratifying IR in adolescents with obesity. Methods: Cytokines [tumour cell derived factor 1α, monocyte chemoattract protein (MCP) 1, eotaxin and fractalkine], growth factors [brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor (PDGF-BB) and insulin-like growth factor 1] and biochemical/metabolic factors were analysed in serum of 143 pubertal patients with obesity (50% IR; 50% non-IR) and 33 controls. Factor analysis, correlation, binary logistic regression and receiver operating characteristic analysis were used to evaluate combinations of these biomarkers as possible diagnostic tools for IR. Results: Two biomarker IR models combining levels of triglycerides (TG)/HDL, eotaxin, MCP-1 and PDGF-BB in pubertal patients with obesity of both sexes were defined. Altered levels of MCP-1, eotaxin, and PDGF-BB constitute a main component that determines 27.7% of the variance explaining IR. Growth and inflammatory factors comprise two other components linked to the first, together accounting for 59.2% of the variance determining IR. Conclusions: PDGF-BB, MCP-1, eotaxin, TG and cholesterol concentrations constitute a solid panel of biomarkers associated with IR in pubertal children with obesity that could be useful in their stratification in a clinical setting for stratification. Rivera P, Martos-Moreno GÁ, Barrios V, Suárez J, Pavón FJ, Chowen JA, Rodríguez de Fonseca F, Argente J. A combination of circulating chemokines as biomarkers of obesity-induced insulin resistance at puberty. Pediatr Obes. 2021 Feb;16(2):e12711. doi: 10.1111/ijpo.12711 https://hdl.handle.net/10630/40385 10.1111/ijpo.12711 Obesidad Obesidad en adolescentes A combination of circulating chemokines as biomarkers of obesity-induced insulin resistance at puberty