2026-05-28T06:18:08Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/404702026-02-03T10:54:00Zcom_10630_2254col_10630_37953

Moncho-Jordá, Arturo Jódar-Reyes, Ana Belén Kanduc, Matej Germán-Bellod, Alicia López-Romero, Juan Manuel Contreras-Cáceres, Rafael Sarabia-García, Francisco Ramón Garcia-Castro, Miguel Pérez-Ramírez, Héctor Odriozola, Gerardo 2025-10-28T08:02:18Z 2025-10-28T08:02:18Z 2020-11-11 Arturo Moncho-Jordá, Ana B. Jódar-Reyes, Matej Kanduč, Alicia Germán-Bellod, Juan M. López-Romero, Rafael Contreras-Cáceres, Francisco Sarabia, Miguel García-Castro, Héctor A. Pérez-Ramírez, and Gerardo OdriozolaScaling Laws in the Diffusive Release of Neutral Cargo from Hollow Hydrogel Nanoparticles: Paclitaxel-Loaded Poly(4-vinylpyridine) ACS Nano 2020 14 (11), 15227-15240 DOI: 10.1021/acsnano.0c05480 https://hdl.handle.net/10630/40470 10.1021/acsnano.0c05480 We study the nonequilibrium diffusive release of electroneutral molecular cargo encapsulated inside hollow hydrogel nanoparticles. We propose a theoretical model that includes osmotic, steric, and short-range polymer−cargo attractions to determine the effective cargo−hydrogel interaction, ueff*, and the effective diffusion coefficient of the cargo inside the polymer network, Deff*. Using dynamical density functional theory (DDFT), we investigate the scaling of the characteristic release time, τ1/2, with the key parameters involved in the process, namely, ueff*, Deff*, and the swelling ratio. This effort represents a full study of the problem, covering a broad range of cargo sizes and providing predictions for repulsive and attractive polymer shells. Our calculations show that the release time through repulsive polymer networks scales with q2eβueff*/Deff* for βueff * ≫ 1. In this case, the cargo molecules are excluded from the shell of the hydrogel. For attractive shells, the polymer retains the cargo molecules on its internal surface and its interior, and the release time grows exponentially with the attraction strength. The DDFT calculations are compared to an analytical model for the mean first passage time, which provides an excellent quantitative description of the kinetics for both repulsive and attractive shells without fitting parameters. Finally, we apply the method to reproduce experimental results on the release of paclitaxel from hollow poly(4-vinylpyridine) nanoparticles and find that the slow release of the drug can be explained in terms of the strong binding attraction between the drug and the polymer. eng open access Funcionales de densidad Coloides Cinética Scaling Laws in the Di usive Release of Neutral Cargo from Hollow Hydrogel Nanoparticles: Paclitaxel-Loaded Poly(4- vinylpyridine). journal article