2026-05-30T07:02:47Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/404782026-02-03T11:11:03Zcom_10630_2254col_10630_37953

Isolation and Antitumoral Effect of a New Siphonochilone Derivative from African Ginger. Fuentes-Ríos, David Ortigosa, Alba Quiñonero, Francisco Melguizo, Consolación Ortiz, Raúl Prados, José Díaz-Morilla, Amelia López-Romero, Juan Manuel Productos naturales Compuestos bioactivos vegetales Antineoplásicos Jengibre - Uso terapeútico A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3- b]furan-5-yl acetate (1), has been isolated from the rhizomes of the South African variety of wild ginger (Siphonochilus aethiopicus (Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclear magneticresonance spectroscopy(NMR) and mass-spectrometric (MS)analyses, including 1D-, 2D-NMR,and HR-LCMS. We also investigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous system cancer lines. The data are not encouraging since its antitumor effect is poor. Nonetheless, the discovery of new molecules may provide a source of new compounds with important biological effects applicable to the field of medicine. 2025-10-28T12:03:36Z 2025-10-28T12:03:36Z 2024-03-20 journal article ACS Omega 2024, 9, 15718−15722 https://hdl.handle.net/10630/40478 10.1021/acsomega.4c01914 eng open access ACS