2026-06-01T10:23:59Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/405232026-02-03T11:03:44Zcom_10630_2254col_10630_37953

Long-term prognostic implications of type 2 diabetes mellitusin colorectal cancer patients Alcaide, Julia Boughanem Lakhal, Hatim García Aranda, Marilina Rivas-Ruiz, Francisco Aguirre, Urko Martin-García, Desirée Padilla- Ruiz, María Varela-Moreno, Esperanza Robles-Lasarte, Marta Baré, Marisa Del Cura, Isabel Morales-Suárez-Varela, María Manuela Quintana, José María Macías-González, Manuel Redondo-Bautista, Maximino Cáncer colorrectal Depresión mental Diabetes Cáncer -- Factores de riesgo Aim: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide.Epidemiological evidence has identified Type 2 Diabetes Mellitus (T2DM) as a risk factorfor CRC. This study aimed to evaluate the impact of T2DM, along with clinicopathologicaland socio-demographic factors, on long-term overall survival in a large, nationally repre-sentative cohort of CRC patients with T2DM.Method: A prospective cohort of 1186 CRC patients was analysed, approximately 20% ofwhom had a diagnosis of T2DM. Kaplan–Meier estimates and multivariable Cox propor-tional hazards models were used to assess overall survival.Results: CRC patients with T2DM were more often older, had lower educational attain-ment, were former smokers, and presented higher comorbidity, right-sided tumours, priorsymptoms, depressive symptoms, elevated Body Mass Index (BMI) and lower baselinequality of life (EORTC QLQ-C30 < 75). In multivariable analysis, the co-occurrence of T2DMand depression (p = 0.007; HR 1.77; 95% CI: 1.17–2.68) and low quality of life (p = 0.04; HR1.42; 95% CI: 1.02–1.97) emerged as independent predictors of poorer long-term survival.Conclusion: Our findings highlight the compounded negative impact of T2DM and depres-sion on overall survival in CRC patients. Their combined presence significantly worsensprognosis, underscoring the need for integrated care approaches that address both physi-cal and mental health. Future research should explore targeted interventions for these co-morbidities to improve long-term outcomes and quality of life in this high-risk population. 2025-10-30T09:55:53Z 2025-10-30T09:55:53Z 2025-10-30T09:55:53Z 2025 journal article Alcaide-Garcia, J., Boughanem, H., García-Aranda, M., Rivas-Ruiz, F., Aguirre, U., García, D. M., Padilla-Ruiz, M., Varela-Moreno, E., Robles-Lasarte, M., Baré, M., Del Cura, I., Morales-Suárez Varela, M. M., Quintana, J. M., Macías, M., & Redondo, M. (2025). Long-term prognostic implications of type 2 diabetes mellitus in colorectal cancer patients. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 27(10), e70250. https://doi.org/10.1111/codi.70250 https://hdl.handle.net/10630/40523 10.1111/codi.70250 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley