2026-06-01T01:04:54Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/405262026-02-03T10:58:13Zcom_10630_2254col_10630_37953

Standardizing single-cell approaches to osteoarthritis: Toward a comprehensive cellular atlas Delgado-Sánchez, Iván Fernández-Pozo, Noé Durán-Jimenez, Iván Jesús Artrosis Citología Acido ribonucleico Osteoarthritis (OA) is a degenerative joint disease marked by progressive cartilage degradation and complex cellular heterogeneity. In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for dissecting the cellular composition of the osteoarthritic joint. However, constructing a complete and coherent picture of the OA single-cell landscape remains challenging, akin to assembling a puzzle from multiple sets, each with pieces of varying shapes and sizes. This editorial outlines the next steps in advancing single-cell research in OA, emphasizing the need for standardized cell type annotations and comprehensive, integrative access to both historical and newly generated datasets. 2025-10-30T11:14:02Z 2025-10-30T11:14:02Z 2025 journal article Delgado-Sanchez, I., Fernandez-Pozo, N., & Duran, I. (2025). Standardizing single-cell approaches to osteoarthritis: Toward a comprehensive cellular atlas. Osteoarthritis and Cartilage. Advance online publication. https://doi.org/10.1016/j.joca.2025.08.016 https://hdl.handle.net/10630/40526 10.1016/j.joca.2025.08.016 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier