2026-05-30T01:33:28Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/405312026-02-03T11:27:33Zcom_10630_2254col_10630_37953

Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis. Ortigosa-Palomo, Alba Fuentes-Ríos, David Quiñonero, Francisco Melguizo, Consolación Ortiz, Raúl López-Romero, Juan Manuel Prados, José Jengibre - Uso terapeútico Células - Muerte Citotoxicidad por mediación celular Plants provide a wide array of compounds that can be explored for potential antican- cer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested. The aim of this study was to analyze the cytotoxic effects of siphonochilone on a panel of cancer cell lines and its underlying mechanism of action. Our results demonstrated that siphonochilone exhibited significant cytotoxic effects on pancreatic, breast, lung, colon, and liver cancer cell lines showing a IC50 ranging from 22 to 124 μM at 72 h of treatment and highlighting its cytotoxic effect against MCF7 and PANC1 breast and pancreas cancer cell lines (22.03 and 39.03 μM, respectively). Cell death in these tumor lines was mediated by apoptosis by the mitochondrial pathway, as evidenced by siphonochilone-induced depolarization of the mitochondrial membrane potential. In addition, siphonochilone treatment involves the generation of reactive oxygen species that may contribute to apoptosis induction. In this work, we described for the first time the cytotoxic properties of siphonochilone and provided data about the molecular processes of cell death. Although future studies will be necessary, our results support the interest in this molecule in relation to their clinical application in cancer, and especially in breast and pancreatic cancer. 2025-10-30T12:39:58Z 2025-10-30T12:39:58Z 2024-04-23 journal article Environmental Toxicology. 2024;1–14. https://hdl.handle.net/10630/40531 10.1002/tox.24308 eng http://creativecommons.org/licenses/by-nd/4.0/ open access Attribution-NoDerivatives 4.0 Internacional Wiley