2026-06-01T10:16:37Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/405802026-02-03T11:35:23Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Mari-Beffa, Manuel
author
Segura-Egea, Juan José
author
Díaz-Cuenca, Aránzazu
2025-11-03T13:01:30Z
2025-11-03T13:01:30Z
2017-01-01
Marí-Beffa, M., Segura-Egea, J. J., & Díaz-Cuenca, A. (2017). Regenerative Endodontic Procedures: A Perspective from Stem Cell Niche Biology. Journal of endodontics, 43(1), 52–62. https://doi.org/10.1016/j.joen.2016.09.011
https://hdl.handle.net/10630/40580
10.1016/j.joen.2016.09.011
Introduction: Endodontics uses cell therapy strategies
to treat pulpal and periapical diseases. During these
therapies, surgeons aim to reconstruct the natural microenvironments
that regulate the activity of dental
stem cells. Methods: We searched for more than 400
articles in PubMed using key words from regenerative
endodontics and dental stem cell biology. In 268 articles,
we reviewed what factors may influence histologic
results after preclinical dental treatments that use
regenerative endodontic procedures after pulpectomy.
Results: Several factors, such as the origin of stem cells,
the biomimicry of scaffolds used, and the size of lesions,
are considered to influence the histologic appearance of
the regenerated pulp-dentin complex after treatments.
Information is accumulating on transcription factors
that generate the pulp-dentin complex and survival/trophic
factors that would benefit niche recovery and histologic
results. Conclusions: In this article, we discuss the
noninterchangeability of stem cells, the influence of
dentin-entrapped molecule release on pulp regeneration
and survival of stem cells, and the need of positional
markers to assess treatments histologically. The
ex vivo amplification of appropriate dental stem cells,
the search for scaffolds storing the molecular diversity
entrapped in the dentin, and the use of positional transcription
factors as histologic markers are necessary to
improve future preclinical experiments.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Endodoncia
Células madre
Investigación científica - Uso terapéutico
Regenerative Endodontic Procedures: A Perspective from Stem Cell Niche Biology.
journal article
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