2026-06-05T12:29:15Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/408522026-06-02T10:19:13Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Pinto-Medel, María Jesús
author
Oliver-Martos, Begoña
author
Urbaneja-Romero, Patricia
author
Hurtado-Guerrero, Isaac
author
Ortega-Pinazo, Jesús
author
Serrano-Castro, Pedro Jesús
author
Fernández-Fernández, Óscar
author
Leyva-Fernández, Laura
2025-11-20T12:31:39Z
2025-11-20T12:31:39Z
2017-08-18
Pinto-Medel MJ, Oliver-Martos B, Urbaneja-Romero P, Hurtado-Guerrero I, Ortega-Pinazo J, Serrano-Castro P, Fernández Ó, Leyva L. Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment. Sci Rep. 2017 Aug 18;7(1):8727. doi: 10.1038/s41598-017-09301-2. PMID: 28821874; PMCID: PMC5562733.
https://hdl.handle.net/10630/40852
10.1038/s41598-017-09301-2
The alteration of DNA methylation patterns are a key component of disease onset and/or progression.
Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1)
methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis
(MS) patients and healthy controls. In addition, we assessed the association of LINE-1 methylation
with clinical disease activity in patients treated with IFNbeta (IFNβ). We found that individuals with
high levels of LINE-1 methylation showed 6-fold increased risk of suffering MS. Additionally, treated
MS patients who bear high LINE-1 methylation levels had an 11-fold increased risk of clinical activity.
Moreover, a negative correlation between treatment duration and percentage of LINE-1 methylation,
that was statistically significant exclusively in the group of patients without clinical activity, was
observed. Our data suggest that in MS patients, a slight global DNA hypermethylation occurs that may
be related to the pathophysiology of the disease. In addition, global DNA methylation levels could play
a role as a biomarker for the differential clinical response to IFNβ.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Esclerosis múltiple - Tratamiento
Metilación
Biología molecular
Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment.
journal article
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Sci Rep 2017_ vol 7.pdf