2026-05-31T08:21:37Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/409742026-04-16T06:59:20Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Domínguez-Pera, Ignacio
author
Estebanez-Perez, María Jose
author
Pastora-Bernal, Jose Manuel
author
Martín-Valero, Rocío
author
Lucena-Antón, David
author
Estebanez Pérez, María José
author
Pastora-Bernal, José Manuel
2025-12-02T10:53:21Z
2025-12-02T10:53:21Z
2025-10-09
Domínguez-Pera, I., Lucena-Anton, D., Estebanez-Perez, M. J., Pastora-Bernal, J. M., & Martín-Valero, R. (2025). Efficacy of transcranial direct current stimulation combined with gait training in patients with Parkinson's disease: Systematic review and meta-analysis. CNS spectrums, 30(1), e79. https://doi.org/10.1017/S1092852925100618
https://hdl.handle.net/10630/40974
10.1017/S1092852925100618
Parkinson’s disease, the second most prevalent neurological disorder, is a multisystem neurodegenerative disease characterized by both motor and non-motor symptoms. Transcranial direct current stimulation (tDCS) is a non-invasive brain neuromodulation technique that has been shown to be effective in some neurological conditions and for some clinical outcomes. To evaluate the efficacy of tDCS combined with gait training in Parkinson’s disease, compared to placebo, absence of treatment, conventional therapy, or other therapies. A systematic review and meta-analysis were performed in accordance with the PRISMA guidelines and registered in PROSPERO CRD42024542552. The literature search was conducted in PubMed, CINAHL, SPORT Discus, Web of Science, Scopus, MEDLINE, and Academic Search Ultimate (EBSCO) databases up to May 2024, limited to trials from the last 10 years. A total of 600 articles were identified; 9 were included in the systematic review and 8 in the meta-analysis. Significant intra-group changes were observed, but in the meta-analysis, no significant differences were seen between tDCS + gait training and tDCS placebo + gait training, although variables such as motor function slightly favored the combination (MD = −0.49; 95% CI [−1.55; 0.57], I2 = 0%). The combination of tDCS and gait training could provide significant motor benefits in terms of gait speed, functional mobility, cadence, motor function, quality of life, 6MWT, coordination and dynamic balance, flexibility, and stretch resistance in patients with Parkinson’s disease, but not in a more effective way than the same training without stimulation.
eng
Attribution 4.0 Internacional
Parkinson, Enfermedad de
Trastornos motores
Sistema nervioso - Enfermedades
Efficacy of transcranial direct current stimulation combined with gait training in patients with Parkinson's disease: Systematic review and meta-analysis.
journal article
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efficacy-of-transcranial-direct-current-stimulation-combined-with-gait-training-in-patients-with-parkinsons-disease-systematic-review-and-meta-analysis (1).pdf