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oai:riuma.uma.es:10630/411632026-02-03T11:26:57Zcom_10630_2254col_10630_37953

Herrera-Gutiérrez, Manuel Enrique Seller Pérez, Gemma Luisa Sánchez Izquierdo Riera, José Ángel Maynar Moliner, Javier 2025-12-17T10:45:55Z 2025-12-17T10:45:55Z 2013-10 Herrera-Gutiérrez ME, Seller-Pérez G, Sánchez-Izquierdo-Riera JA, Maynar-Moliner J; COFRADE investigators group. Prevalence of acute kidney injury in intensive care units: the "COrte de prevalencia de disFunción RenAl y DEpuración en críticos" point-prevalence multicenter study. J Crit Care. 2013 Oct;28(5):687-94. doi: 10.1016/j.jcrc.2013.05.019. Epub 2013 Jul 8. PMID: 23845794. https://hdl.handle.net/10630/41163 10.1016/j.jcrc.2013.05.019 Purpose: This study aimed to measure the point prevalence of kidney dysfunction (KD) in the intensive care setting. Materials and methods: A point-prevalence, single-day, prospective study was conducted. Of 919 patients present in 42 Intensive care units (ICUs) for 2 specific days (September 2009 and March 2010), 832 cases were included. Mild KD was defined as a measured creatinine clearance of 90 to 60 mL min(-1) 1.73 m(-2), and severe KD was defined as a creatinine clearance less than 60 mL min(-1) 1.73 m(-2). Results: Prevalence of mild KD was 15.9/100 patients/d (13.5-18.5), and severe KD was 42.4/100 patients/d (39.1-45.8). We considered as having a low probability of experiencing KD those patients without chronic kidney disease, acute kidney injury network stage 0, and a serum creatinine less than 1.2 mg/dL, but among them (557 patients), 18.1% (15.2%-21.6%) had mild KD and 24.2% (20.9%-28%) had severe KD. ICU mortality was 10.6% (7.81%-14.4%) for patients without dysfunction, 16.6% (11.2%-24%) for patients with mild KD, and 29.7% (25.2%-34.7%; P<.001) for patients with severe KD, with a relative risk for severe KD vs no KD of 2.54 (1.90-3.40). In 54.3% patients, at least 1 renal insult was reported. One nephrotoxic drug was administered to 34.4% and 2 or more to 14.9% patients, with a lower frequency among those with chronic kidney disease (30.6% vs 50.8%; P<.05). Conclusions: Each day of study, more that half of the patients admitted to the ICU showed some derangement in kidney function. More than 25% of patients not fulfilling the KD criteria by serum creatinine or acute kidney injury network showed, in fact, a severe KD, and this finding was associated with higher mortality. More than 50% of the patients admitted to the ICU were subjected to at least 1 renal insult. eng open access Insuficiencia renal aguda Riñones - Enfermedades Prevalence of acute kidney injury in intensive care units: The “COrte de prevalencia de disFunción RenAl y DEpuración en críticos” point-prevalence multicenter study journal article