2026-05-28T16:35:32Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/411642026-02-03T11:25:41Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Herrera-Gutiérrez, Manuel Enrique
author
Seller Pérez, Gemma Luisa
author
Arias Verdú, Dolores
author
Granados, Maria M.
author
Domínguez, Juan M.
author
Navarrete, Rocío
author
Morgaz, Juan
author
Gómez Villamandos, Rafael
2025-12-17T10:46:29Z
2025-12-17T10:46:29Z
2012-04-10
Herrera-Gutiérrez ME, Seller-Pérez G, Arias-Verdú D, Granados MM, Dominguez JM, Navarrete R, Morgaz J, Gómez-Villamandos R. A comparison of the effect of convection against diffusion in hemodynamics and cytokines clearance in an experimental model of septic shock. J Trauma Acute Care Surg. 2012 Oct;73(4):855-60. doi: 10.1097/TA.0b013e31825eea8a. PMID: 22922966. Copy Download .nbib For
https://hdl.handle.net/10630/41164
10.1097/TA.0b013e31825eea8a
BACKGROUND: Our aim was to define the efficacy of hemofiltration (convection) and hemodialysis (diffusion) in cytokine clearance and hemodynamic
improvement in an experimental model of septic shock.
METHODS: Shock was induced in 15 beagle dogs (weight 10Y15 kg) by infusion of 1 mg/kg of ultrapure Escherichia coli lipopolysaccharide
diluted in 20 mL saline for 10 minutes. Five animals were followed without interventions (controls), five animals were treated with
convection (100 mL kgj1 hj1) for 6 hours, and five animals were treated with diffusion (100 mL kgj1 hj) for 6 hours.
RESULTS: All subjects in the control group died during the study, whereas all treated subjects survived. Mean arterial pressure, cardiac output,
systolic variability volume, systemic vascular resistances, dPMax, and pulmonary compliance improved in treated subjects. However,
the differences in mean arterial pressure and cardiac output were significant only in the convection group and not in the diffusiontreated
group.
Tumor necrosis factor > rose equally in all groups and decreased only in treated subjects. Interleukin 6 rose in the three groups but
decreased only in the convection group and remained unchanged in the control and diffusion groups.
CONCLUSION: Convection and diffusion improved survival and hemodynamic parameters in a septic shock model. Improvement was more pronounced
with convection, a difference that may be explained by convective clearance of cytokines.
eng
Citoquinas
Enfermedades - Modelos animales
Hemodinámica
A comparison of the effect of convection against diffusion in hemodynamics and cytokines clearance in an experimental model of septic shock
journal article
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2012 Journal of Trauma.pdf