2026-06-01T23:32:23Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/412542026-02-03T11:22:48Zcom_10630_2254col_10630_37953

Gonzalez Fernandez, M Quiles Trasobares, N Barea Mendoza, JA Molina Collado, Zaira Arias Verdú, Dolores Barrueco Francioni, Jesus Emilio Seller Pérez, Gemma Luisa Herrera-Gutiérrez, Manuel Enrique Sánchez Izquierdo Riera, José Ángel 2025-12-19T09:54:43Z 2025-12-19T09:54:43Z 2023-04 González-Fernández M, Quílez-Trasobares N, Barea-Mendoza JA, Molina-Collado Z, Arias-Verdú D, Barrueco-Francioni J, Seller-Pérez G, Herrera-Gutiérrez ME, Sánchez-Izquierdo Riera JA. Evaluation of the registry DIALYREG for the assessment of continuous renal replacement techniques in the critically ill patient. Sci Rep. 2023 Apr 20;13(1):6479. doi: 10.1038/s41598-023-32795-y. PMID: 37081011; PMCID: PMC10117243. https://hdl.handle.net/10630/41254 doi: 10.1038/s41598-023-32795-y Continuous renal replacement techniques (CRRT) can induce complications and monitoring is crucial to ensure patient safety. We designed a prospective multicenter observational and descriptive study using the DIALYREG registry, an online database located on a REDCap web-based platform that allows real-time data analysis. Our main objective was to identify CRRT-related complications in our intensive care units (ICUs) and implement security measures accordingly. From January 2019 to December 2020, we included 323 patients with admission diagnoses of medical illness (54%), sepsis (24%), postoperative care (20%), and trauma (2%). CRRT indications were homeostasis (42%), oliguria (26%), fluid overload (15%), and hemodynamic optimization (13%). The median initial therapy dose was 30 ml/kg/h (IQR 25-40), and dynamic adjustment was performed in 61% of the treatments. Sets were anticoagulated with heparin (40%), citrate (38%) or no anticoagulation (22%). Citrate anticoagulation had several advantages: more frequent dynamic CRRT dose adjustment (77% vs. 58% with heparin and 56% without anticoagulation, p < 0.05), longer duration of set (median of 55 h, IQR 24-72 vs. 23 h, IQR 12-48 with heparin and 12 h, IQR 12-31 without anticoagulation, p < 0.05), less clotting of the set (26% vs. 46.7% with heparin, p < 0.05), and lower incidence of hypophosphatemia (1% citrate vs. 6% with heparin and 5% without anticoagulation). It was also safe and effective in subgroup analysis of patients with liver disease or sepsis. The main global complications were hypothermia (16%), hypophosphatemia (13%) and metabolic acidosis (10%). Weaning of the therapy was achieved through early discontinuation (56%), nocturnal therapy transition (26%) and progressive SLED (18%). 52% of the patients were discharged from the hospital, while 43% died in the ICU and 5% died during hospitalization. We can conclude that the DIALYREG registry is a feasible tool for real-time control of CRRT in our ICU. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Dialyreg - Bases de datos Evaluation of the registry DIALYREG for the assessment of continuous renal replacement techniques in the critically ill patient journal article