2026-05-29T22:45:19Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/412592026-02-03T11:35:40Zcom_10630_2254col_10630_37953

Quiles Trasobares, Nerea Gonzalez Fernandez, Maria Barea Mendoza, Jesus Abelardo Arias Verdú, Dolores Barrueco Francioni, Jesus Emilio Seller Pérez, Gemma Luisa Molina Collado, Zaira Lesmes Gonzalez-de-Aledo, Amanda Herrera-Gutiérrez, Manuel Enrique Sánchez Izquierdo Riera, José Ángel 2025-12-19T10:10:29Z 2025-12-19T10:10:29Z 2024-10 Quílez Trasobares N, González-Fernández M, Barea-Mendoza JA, Arias-Verdú MD, Barrueco-Francioni JE, Seller-Pérez G, Molina-Collado Z, Lesmes González-de Aledo A, Herrera-Gutiérrez M, Sánchez-Izquierdo Riera JÁ. The Role of Immunomodulatory Therapy with Oxiris in COVID-19 with Renal Failure and Immune Dysfunction. Blood Purif. 2024;53(10):804-812. doi: 10.1159/000539833. Epub 2024 Jul 22. PMID: 38991521. https://hdl.handle.net/10630/41259 10.1159/000539833 Introduction: The main objective of this study was to evaluate the impact of hemoadsorption on the elimination of inflammatory mediators. Methods: A prospective, bicenter, observational cohort study was conducted between March 2020 and February 2022 to explore the immunomodulatory response, demographic and clinical characteristics of individuals with COVID-19 admitted to the ICU with severe acute respiratory failure and in need of CRRT with Oxiris® with or without AKI. Results: Sixty-four patients were analyzed. Statistically significant differences were observed between exposed and unexposed groups, in relation to the reduction in D-dimer levels -15,614 (24,848.9) versus -4,136.5 (9,913.47) (p 0.031, d: 1.59, 95% CI: -21,830, -1,126). An increase in PCT was observed 0.47 (2.08) versus -0.75 (2.3) (p 0.044 95% CI: 0.03, 2.44). No differences were found in a decrease in CRP -4.21 (7.29) versus -1.6 (9.02) (p 0.22) nor in the rest of inflammatory parameters fibrinogen, IL-6, ferritin, lymphocytes, and neutrophils. Subgroup analysis in patients exposed to therapy also showed a significant decrease in D-dimer of 55% from baseline: 6,000 (1,984.5-27,750) pre-therapy versus 2,700 (2,119.5-6,145) (95% CI: -23,000, -2,489) post-therapy with a strong effect size (p 0.001, d: 0.65). Conclusion: The hemoadsorptive therapy in COVID-19 was associated with a significant decrease in D-dimer parameters without showing decreases in the rest of the clinical, inflammatory parameters and severity scales analyzed. eng open access COVID-19 Sistema inmunológico The Role of Immunomodulatory Therapy with Oxiris in COVID-19 with Renal Failure and Immune Dysfunction journal article