2026-05-27T23:27:07Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/413632026-02-03T11:06:53Zcom_10630_2254col_10630_37953
Normothermic Regional Perfusion vs. Super-Rapid Recovery in Controlled Donation After Circulatory Death Liver Transplantation
Hessheimer, Amelia J.
Coll, Elisabeth
Torres, Ferrán
Ruiz, Patricia
Gastaca, Mikel
Rivas, José Ignacio
Gómez, Manuel
Sánchez-Pérez, Belinda
Santoyo, Julio
Ramírez, Pablo
Parrilla, Pascual
Marín, Luis Miguel
Gomez-Bravo, Miguel Angel
García-Valdecasas, Juan Carlos
López-Monclús, Javier López
Boscá, Andrea
López-Andujar, Rafael
Fundora-Suárez, Jiliam
Villar, Jesús
García-Sesma, Alvaro
Jiménez, Carlos
Rodríguez-Laíz, Gonzalo
LLadó, Laura
Rodríguez, Juan Carlos
Barrera, Manuel
Charco, Ramón
López-Baena, Jose Ángel
Briceño, Javier
Pardo, Fernando
Blanco, Gerardo
Pacheco, David
Domínguez-Gil, Beatriz
Sánchez Turrión, Víctor
Fondevila, Constatino
rivas, jose ignacio
Hígado - Trasplante
Background & Aims: Although there is increasing interest in its
use, definitive evidence demonstrating a benefit for postmortem
normothermic regional perfusion (NRP) in controlled donation
after circulatory death (cDCD) liver transplantation is lacking.
The aim of this study was to compare results of cDCD liver
transplants performed with postmortem NRP vs. super-rapid
recovery (SRR), the current standard for cDCD.
Methods: This was an observational cohort study including all
cDCD liver transplants performed in Spain between June 2012
and December 2016, with follow-up ending in December
2017. Each donor hospital determined whether organ recovery
was performed using NRP or SRR. The propensity scores technique
based on the inverse probability of treatment weighting
(IPTW) was used to balance covariates across study groups;
logistic and Cox regression models were used for binary and
time-to-event outcomes.
Results: During the study period, there were 95 cDCD liver
transplants performed with postmortem NRP and 117 with
SRR. The median donor age was 56 years (interquartile range
45–65 years). After IPTW analysis, baseline covariates were balanced,
with all absolute standardised differences <0.15. IPTWadjusted
risks were significantly improved among NRP livers
for overall biliary complications (odds ratio 0.14; 95% CI 0.06–
0.35, p <0.001), ischaemic type biliary lesions (odds ratio 0.11;
95% CI 0.02–0.57; p = 0.008), and graft loss (hazard ratio 0.39;
95% CI 0.20–0.78; p = 0.008).
Conclusions: The use of postmortem NRP in cDCD liver transplantation
appears to reduce postoperative biliary complications,
ischaemic type biliary lesions and graft loss, and allows
for the transplantation of livers even from cDCD donors of
advanced age.
2026-01-09T09:28:08Z
2026-01-09T09:28:08Z
2019
journal article
Hessheimer AJ, Coll E, Torres F, Ruíz P, Gastaca M, Rivas JI, Gómez M, Sánchez B, Santoyo J, Ramírez P, Parrilla P, Marín LM, Gómez-Bravo MÁ, García-Valdecasas JC, López-Monclús J, Boscá A, López-Andújar R, Fundora-Suárez J, Villar J, García-Sesma Á, Jiménez C, Rodríguez-Laíz G, Lladó L, Rodríguez JC, Barrera M, Charco R, López-Baena JÁ, Briceño J, Pardo F, Blanco G, Pacheco D, Domínguez-Gil B, Sánchez Turrión V, Fondevila C. Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation. J Hepatol. 2019 Apr;70(4):658-665. doi: 10.1016/j.jhep.2018.12.013. Epub 2018 Dec 22. PMID: 30582980.
https://hdl.handle.net/10630/41363
10.1016/j.jhep.2018.12.013
eng
http://creativecommons.org/licenses/by-nc-nd/4.0/
open access
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Elsevier