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oai:riuma.uma.es:10630/446522026-02-03T11:35:55Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Cortés-Rodríguez, Miriam author Reyes Palomares, Arturo author Lendinez, Ana author Ruiz-Galdón, Maximiliano author Reyes-Engel, Armando author 2018-05-01 Spermatozoa and neurones share similar membrane characteristics and features. Associations of multiple polymorphisms traditionally related to neurotransmission were investigated. Infertile men were grouped into controls with normospermia (n = 182) and idiopathic infertile men with asthenozoospermia (n = 103), and analysed as a case-control study and as a quantitative association of each genotype. Ten neurotransmission-associated genetic variants were mapped by SNP analysis using quantitative polymerase chain reaction with TaqMan probes. Men with HTR2A rs6313 had a higher risk of asthenozoospermia (OR = 2.14; P = 0.04). MAOA rs3788862 G carriers displayed an increased risk of asthenozoospermia (OR = 2.29; P = 0.02). The SLC18A1 rs1390938 G allele was more frequent among such cases (0.75 versus 0.87; P < 0.01 and P < 0.01 for Armitage trend test); for SLC18A1 rs2270641 P = 0.02 (case-control frequency) and P = 0.01 (Armitage trend test). MAOA rs3788862 was correlated with sperm motility (Spearman ρ = 0.14; P = 0.02); SLC18A1 rs1390938 was correlated with sperm count and motility (Spearman ρ = 0.20; P < 0.01). Gene polymorphisms of HTR2A, MAOA and SLC18A1, related to neurotransmission, are individually associated with asthenozoospermia through variation in sperm count and motility, without detectable allelic or genotype interaction. Miriam Cortés-Rodriguez, Jose-Luis Royo, Arturo Reyes-Palomares, Ana M. Lendínez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel, Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A, Reproductive BioMedicine Online, Volume 36, Issue 5, 2018, Pages 560-567, ISSN 1472-6483, https://hdl.handle.net/10630/44652 10.1016/j.rbmo.2018.01.007 Espermatozoides Esterilidad masculina Sperm count and motility are quantitatively affected by functional polymorphism of classically related to neurotransmitters mood regulators HTR2A, MAOA and SLC18A.