2026-05-30T00:57:59Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/446762026-02-03T10:56:21Zcom_10630_2254col_10630_37953

Prenatal Diagnosis of Peters-Plus Syndrome: A Case Report Fortún-Agud, Marina Monís-Rodríguez, Susana Narbona-Arias, Isidoro Andérica-Herrero, José Ramón Gómez-Muñoz, Cristina Blasco-Alonso, Marta Jiménez-López, Jesús Salvador Diagnóstico prenatal Obstetricia Peters-Plus syndrome is a rare autosomal recessive disorder caused by biallelic pathogenic variants in the B3GLCT gene and characterized by multisystem involvement. Fewer than 100 cases have been reported to date, and only a limited number have been diagnosed prenatally. Prenatal identification is challenging due to the variable and non-specific nature of fetal findings and the frequent absence of detectable ocular anomalies during routine ultrasound. We report a prenatal diagnosis of Peters-Plus syndrome in a monochorionic diamniotic twin pregnancy, based on the progressive identification of early-onset intrauterine growth restriction, rhizomelic limb shortening, craniofacial dysmorphism, and mild central nervous system abnormalities. Standard cytogenetic and chromosomal microarray analyses were normal, prompting extended genetic testing. Prenatal exome sequencing identified a homozygous pathogenic splice-site variant (c.660+1G>A) in B3GLCT in both fetuses, confirming the diagnosis. This case highlights the importance of recognizing suggestive multisystem prenatal findings and the crucial role of advanced genetic testing in achieving an accurate prenatal diagnosis. Early molecular confirmation enables appropriate parental counseling regarding prognosis, recurrence risk, and future reproductive options. 2026-01-08 journal article Fortún Agud M, Monís Rodríguez S, Narbona Arias I, Andérica Herrero JR, Gómez Muñoz C, Blasco Alonso M, Jiménez López JS. Prenatal Diagnosis of Peters-Plus Syndrome: A Case Report. Life. 2026; 16(1):92. https://doi.org/10.3390/life16010092 2075-1729 https://hdl.handle.net/10630/44676 10.3390/life16010092 eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International MDPI