2026-05-31T23:11:03Zhttps://riuma.uma.es/rest/oai/request
oai:riuma.uma.es:10630/447562026-01-24T00:45:25Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga author Ruiz-Canela, Miguel author Corella, Dolores author Martínez González, Miguel Ángel author Babio, Nancy author Martínez, J. Alfredo author Forga, Luis author Alonso-Gómez, Ángel M. author Warnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramón author Santos-Lozano, José Manuel author Serra-Majem, Luis author Bueno-Cavanillas, Aurora author Tur, Josep A. author Martín-Sánchez, Vicente author Riera-Mestre, Antoni author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Buil-Cosiales, Pilar author Shyam, Sangeetha author Sorlí, José V. author Castañer, Olga author García-Rios, Antonio author Torres-Collado, Laura author Gómez-Gracia, Enrique author Zulet, M. Ángeles author Konieczna, Jadwiga author Casas, Rosa author Cano-Ibáñez, Naomi author Tojal-Sierra, Lucas author Bernal-López, Rosa M. author Toledo, Estefanía author García-Gavilán, Jesús F. author Fernández-Carrión, Rebeca author Goday, Albert author Arenas-Larriva, Antonio P. author González-Palacios, Sandra author Schröder, Helmut author Ros, Emilio author Fitó, Montserrat author Hu, Frank B. author Tinahones-Madueño, Francisco José author Salas-Salvadó, Jordi 2026-01-23T07:43:45Z 2025-10-01 Ruiz-Canela M, Corella D, Martínez-González MÁ, Babio N, Martínez JA, Forga L, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Santos-Lozano JM, Serra-Majem L, Bueno-Cavanillas A, Tur JA, Martín-Sánchez V, Riera-Mestre A, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Buil-Cosiales P, Shyam S, Sorlí JV, Castañer O, García-Rios A, Torres-Collado L, Gómez-Gracia E, Zulet MÁ, Konieczna J, Casas R, Cano-Ibáñez N, Tojal-Sierra L, Bernal-López RM, Toledo E, García-Gavilán J, Fernández-Carrión R, Goday A, Arenas-Larriva AP, González-Palacios S, Schröder H, Ros E, Fitó M, Hu FB, Tinahones FJ, Salas-Salvadó J. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med. 2025 Oct;178(10):1378-1389. doi: 10.7326/ANNALS-25-00388. Epub 2025 Aug 26. PMID: 40854218. https://hdl.handle.net/10630/44756 10.7326/ANNALS-25-00388 Prespecified secondary outcome analysis in the PREDIMED (Prevención con Dieta Mediterránea) Plus randomized, single-blinded, controlled trial. (ISRCTN Registry: ISRCTN89898870) Setting: 23 centers across Spain. Participants: 4746 adults aged 55 to 75 years with metabolic syndrome and overweight or obesity, without prior cardiovascular disease or diabetes. Participants were randomly assigned 1:1 to an intervention group receiving an erMedDiet (planned reduction of 600 kcal per day), increased physical activity, and behavioral strategies for reducing weight, or a control group receiving ad libitum MedDiet advice. Results: During the 6-year intervention period, absolute risk was 12.8% (95% CI, 11.0% to 14.5%) in the control group and 10.3% (CI, 8.8% to 11.8%) in the intervention group; the absolute risk reduction was 2.5% (CI, 4.7% to 0.3%); and the adjusted Hazard ratio was 0.67 (CI, 0.56 to 0.80). When the extended follow-up period beyond the intervention period (range between more than 6 years and 8.6 years) was included, diabetes incidence was 31% (CI, 18% to 41%) relatively lower in the intervention group (280 cases) compared with the control group (349 cases). Limitation: Secondary outcome, single-blinded design, and self-reported dietary adherence. Conclusion: An intensive intervention with the MedDiet adding caloric reduction, physical activity, and modest weight loss was more effective than only an ad libitum MedDiet in reducing diabetes incidence in overweight/ obese persons with metabolic syndrome eng Attribution-NonCommercial-NoDerivatives 4.0 International Medicina preventiva Diabetes tipo 2 - Prevención Alimentación - Mediterráneo (Región) Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes. journal article 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 URL https://riuma.uma.es/bitstreams/65649a14-0724-486e-b62b-c6a1459ac654/download File MD5 a3099ca1e9839c96cb2e69a5701f3237 695245 application/pdf ANNALSc.pdf