2026-05-27T05:30:21Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/453542026-02-12T00:45:26Zcom_10630_2254col_10630_37953

Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study Martín-Peláez, Sandra Serra-Majem, Lluis Cano-Ibáñez, Naomi Martínez-González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Lassale, Camille Martínez, Jose Ángel Alonso-Gómez, Ándres M Warnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco Lapreta, José Fernández-Aranda, Fernando Bueno-Cavanillas, Aurora Tur, Josep Martin, Vicente Pintó, Xavier Delgado-Rodríguez, Miguel Matia, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emili Toledo, Estefanía Nishi, Stephanie Sorli, Jose Malcampo, Mireia Zulet, M. Ángeles Moreno-Rodríguez, Anai Cueto-Galán, Raquel Vivancos-Aparicio, Diego Colom, Antoni García-Ríos, Antonio Casas, Rosa Bernal-López, M. Rosa Santos-Lozano, Jose Manuel Vázquez, Zenaida Gómez-Martínez, Carlos Ortega-Azorín, Carolina Del Val, Jose Luis Abete, Itziar Goikoetxea-Bahon, Amaia Pascual, Elena Becerra-Tomás, Nerea Chillarón, Juan Sánchez-Villegas, Almudena Depresión Corazón - Enfermedades Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55–75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240–279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870). 2026-02-11T08:19:45Z 2022-04-13 journal article Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N, Martínez-González MÁ, Salas-Salvadó J, Corella D, Lassale C, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Fernández-Aranda F, Bueno-Cavanillas A, Tur JA, Martín V, Pintó X, Delgado-Rodríguez M, Matía P, Vidal J, Vázquez C, Daimiel L, Ros E, Toledo E, Nishi SK, Sorli JV, Malcampo M, Zulet MÁ, Moreno-Rodríguez A, Cueto-Galán R, Vivancos-Aparicio D, Colom A, García-Ríos A, Casas R, Bernal-López MR, Santos-Lozano JM, Vázquez Z, Gómez-Martínez C, Ortega-Azorín C, Del Val JL, Abete I, Goikoetxea-Bahon A, Pascual E, Becerra-Tomás N, Chillarón JJ, Sánchez-Villegas A. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. PLoS One. 2022 Apr 13;17(4):e0265079. doi: 10.1371/journal.pone.0265079. PMID: 35417452; PMCID: PMC9007355. 1932-6203 https://hdl.handle.net/10630/45354 10.1371/journal. pone.0265079 eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International PLOS ONE