2026-06-01T15:47:25Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/453952026-04-10T08:44:26Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Oualla-Bachiri, Wasima author Lago-Sampedro, Ana author García-Escobar, Eva author Maldonado- Araque, Cristina author Delgado, Elías author Chaves, Felipe J. author Castaño, Luis author Calle-Pascual, Alfonso author Franch-Nadal, Josep author Olveira-Fuster, Gabriel María author Rojo-Martínez, Gemma author Doulatram- Gamgaram, Viyey author Valdés, Sergio author 2026 Cardiovascular disease (CVD) remains the leading cause of mortality. New biomarkers are needed to improve CVD risk prediction. Several studies have reported associations between surfactant protein D (SP-D), an innate immune system component, and CVD; however, general population studies remain scarce. The main aim of this study was to investigate the association between SP-D and CVD events incidence in the Spanish general adult population.MethodsSocio-demographic, lifestyle (including smoking status) and clinical data from 1707 participants of the di@bet.es cohort without previous CVD events were collected and analysed. CVD events (including both morbidity and mortality) were reported at baseline and after 7.5 years of follow-up. SP-D serum levels were measured by ELISA and categorized in quartiles.ResultsSP-D categories are associated with CVD events incidence, independently from other strong risk factors such as cardiovascular risk scores (SCORE2 and SCORE2-OP), BMI, hs-CRP, or eGFR. Although SP-D has been linked to smoking, SP-D categories predicted CVD events incidence even among non-smokers. The addition of SP-D to multivariate models improved performance in the assessment, predicting 83% of the events with a specificity of 74% and a sensitivity of 84% in the overall population.ConclusionsSP-D may be considered as a promising biomarker of CVD events in combination with other well established factors in clinical practice. Oualla-Bachiri W, Lago-Sampedro A, García-Escobar E, et al. Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study. Eur J Clin Invest. 2026; 56:e70179. doi:10.1111/eci.70179 https://hdl.handle.net/10630/45395 https://doi.org/10.1111/eci.70179 Sistema cardiovascular - Enfermedades Marcadores bioquímicos Corazón - Enfermedades Tabaquismo Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study