2026-05-30T03:49:15Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/453952026-04-10T08:44:26Zcom_10630_2254col_10630_37953

Oualla-Bachiri, Wasima Lago-Sampedro, Ana García-Escobar, Eva Maldonado- Araque, Cristina Delgado, Elías Chaves, Felipe J. Castaño, Luis Calle-Pascual, Alfonso Franch-Nadal, Josep Olveira-Fuster, Gabriel María Rojo-Martínez, Gemma Doulatram- Gamgaram, Viyey Valdés, Sergio 2026-02-12T08:38:21Z 2026 Oualla-Bachiri W, Lago-Sampedro A, García-Escobar E, et al. Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study. Eur J Clin Invest. 2026; 56:e70179. doi:10.1111/eci.70179 https://hdl.handle.net/10630/45395 https://doi.org/10.1111/eci.70179 Cardiovascular disease (CVD) remains the leading cause of mortality. New biomarkers are needed to improve CVD risk prediction. Several studies have reported associations between surfactant protein D (SP-D), an innate immune system component, and CVD; however, general population studies remain scarce. The main aim of this study was to investigate the association between SP-D and CVD events incidence in the Spanish general adult population.MethodsSocio-demographic, lifestyle (including smoking status) and clinical data from 1707 participants of the di@bet.es cohort without previous CVD events were collected and analysed. CVD events (including both morbidity and mortality) were reported at baseline and after 7.5 years of follow-up. SP-D serum levels were measured by ELISA and categorized in quartiles.ResultsSP-D categories are associated with CVD events incidence, independently from other strong risk factors such as cardiovascular risk scores (SCORE2 and SCORE2-OP), BMI, hs-CRP, or eGFR. Although SP-D has been linked to smoking, SP-D categories predicted CVD events incidence even among non-smokers. The addition of SP-D to multivariate models improved performance in the assessment, predicting 83% of the events with a specificity of 74% and a sensitivity of 84% in the overall population.ConclusionsSP-D may be considered as a promising biomarker of CVD events in combination with other well established factors in clinical practice. eng open access Sistema cardiovascular - Enfermedades Marcadores bioquímicos Corazón - Enfermedades Tabaquismo Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study journal article