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oai:riuma.uma.es:10630/454032026-02-13T00:47:24Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Cano-Ballesteros, Sara author Marín-Sedeño, Ernesto author Palmquist-Gomes, Paul author Guadix-Domínguez, Juan Antonio author Pérez-Pomares, José María author 2020-09-13 Fsp1 (a.k.a S100A4 or Metastatin) is an intracellular and secreted protein widely regarded as a fibroblast marker. Recent studies have nonetheless shown that Fsp1 is also expressed by other cell types, including small subsets of endothelial cells. Since no detailed and systematic description of Fsp1 spatio-temporal expression pattern in cardiac vascular cells is available in the literature, we have used a transgenic murine line (Fsp1-GFP) to study Fsp1 expression in the developing and postnatal cardiac vasculature and endocardium. Our work shows that Fsp1 is expressed in the endocardium and mesenchyme of atrioventricular valve primordia, as well as in some coronary venous and lymphatic endothelial cells. Fsp1 expression in cardiac venous and lymphatic endothelium is progressively restricted to the leaflets of cardiac venous and lymphatic valves. Our results suggest that Fsp1 could play a role in the development of atrioventricular valves and participate in the patterning and morphogenesis of cardiac venous and lymphatic vessel valves. Cano-Ballesteros S, Palmquist-Gomes P, Marín-Sedeño E, Guadix JA, Pérez-Pomares JM. Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development. J Anat. 2021 Feb;238(2):508-514. doi: 10.1111/joa.13306. Epub 2020 Sep 13. PMID: 32920869; PMCID: PMC7812130. https://hdl.handle.net/10630/45403 10.1111/joa.13306 Sistema cardiovascular Endotelio Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development