2026-05-30T08:45:07Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/454762026-02-18T00:47:24Zcom_10630_2254col_10630_37959

Use of human bone marrow mesenchymal stem cell exosomes for ependymal repair and edema reduction in posthemorrhagic hydrocephalus treatment Lopez-de-San-Sebastian, Javier Rodríguez-Pérez, Luis Manuel Anguita-Guardia, Alba Jiménez-Lara, Antonio Jesús Páez-González, Patricia Líquido cefalorraquídeo - Congresos Epéndimo - Congresos Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) often lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which acts as a functional and physical barrier between the cerebrospinal fluid and the brain tissue. As a consequence, cerebrospinal fluid circulation and physiology are severely affected; and thus, makes ependyma a chiefly important target when it comes to designing PHH treatments. Bone marrow-derived mesenchymal stem cells (MSCs) are extremely effective anti-inflammatory agents which have already shown positive results in PHH treatment. However, there is no current therapy to recover the ependyma in humans. 2025-09-03 conference output https://hdl.handle.net/10630/45476 eng 20th Meeting of the Spanish Society for Neuroscience Las Palmas de Gran Canaria 03/09/2025 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 International