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oai:riuma.uma.es:10630/456472026-02-24T00:47:07Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Moreno-Indias, Isabel author Oliva Olivera, Wilfredo author Omiste Romero, Antonio Jesús author Castellano Castillo, Daniel author Lhamyani, Said author Camargo, Antonio author Tinahones-Madueño, Francisco José author 2016-06 Discordant phenotypes, metabolically healthy obese and unhealthy normal-weight individuals, are always interesting to provide important insights into the mechanistic link between adipose tissue dysfunction and associated metabolic alterations. Macrophages can release factors that impair the proper activity of the adipose tissue. Thus, studying subcutaneous and visceral adipose tissues, we investigated for the first time the differences in monocyte/macrophage infiltration, inflammation, and adipogenesis of normal-weight subjects who differed in their degree of metabolic syndrome. The study included 92 normal-weight subjects who differed in their degree of metabolic syndrome. Their anthropometric and biochemical parameters were measured. RNA from subcutaneous and visceral adipose tissues was isolated, and mRNA expression of monocyte/macrophage infiltration (CD68, CD33, ITGAM, CD163, EMR-1, CD206, MerTK, CD64, ITGAX), inflammation (IL-6, tumor necrosis factor alpha [TNFα], IL-10, IL-1b, CCL2, CCL3), and adipogenic and lipogenic capacity markers (PPARgamma, FABP4) were measured. Taken together, our data provide evidence of a different degree of macrophage infiltration between the adipose tissues, with a higher monocyte/macrophage infiltration in subcutaneous adipose tissue in metabolically unhealthy normal-weight subjects, whereas visceral adipose tissue remained almost unaffected. An increased macrophage infiltration of adipose tissue and its consequences, such as a decrease in adipogenesis function, may explain why both the obese and normal-weight subjects can develop metabolic diseases or remain healthy. Moreno-Indias I, Oliva-Olivera W, Omiste A, Castellano-Castillo D, Lhamyani S, Camargo A, Tinahones FJ. Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function. Transl Res. 2016 Jun;172:6-17.e3. doi: 10.1016/j.trsl.2016.01.002. Epub 2016 Jan 18. PMID: 26829067. https://hdl.handle.net/10630/45647 10.1016/j.trsl.2016.01.002 Tejido adiposo Metabolismo - Alteraciones Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function