2026-05-27T05:40:57Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/458942026-03-03T07:28:44Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Ofori, Emmanuel K. author Conde Alonso, Sonia author Correas-Gómez, Lorena author Álvarez-Carnero, Elvis author Zwygart, Karin author Hugues, Henry author Bardy, Daniel author Hans, Didier author Dwyer, Andrew A. author Amati, Francesca author 2019 Objective. Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women. Design. Observational, cross-sectional study of healthy, community dwelling postmenopausal women. Patients and Measurements. Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry. Results. Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05). Conclusion. Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity. Ofori EK, Conde Alonso S, Correas‐Gomez L, et al. Thigh and abdominal adipose tissue depotassociations with testosterone levels in postmenopausalfemales. Clin Endocrinol. 2019;90:433–439. https://doi.org/10.1111/cen.13921 https://hdl.handle.net/10630/45894 10.1111/cen.13921 Tejido adiposo Cuerpo humano - Composición Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females