2026-05-31T04:53:37Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/61822026-02-03T12:24:55Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Medina-Torres, Miguel Ángel
author
Rodríguez-Quesada, Ana María
author
Cárdenas García, Casimiro
2013-10-29T12:13:04Z
2013-10-29T12:13:04Z
2013-09-04
Libro de Resúmenes online del XXXVI Congreso SEBBM
http://hdl.handle.net/10630/6182
Although epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated from coffee. The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene contained in unfiltered coffee, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells, with a special incidence on the estrogen receptor-negative MDA-MB231 human breast cancer cells. In these breast cancer cells, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release, both consistent with an activation of the intrinsic pathway of apoptosis. Kahweol also increases the phosphorylation levels of protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) observed in MDA-MB-231 cells. We also demonstrate the inhibitory effect of kahweol on the MDA-MB231 cell potential to migrate and to remodel extracellular matrix by targeting matrix metalloproteinase-9 and urokinase-type plasminogen activator, two key molecules involved in this process. Taken together, our data suggest that, indeed, kahweol behaves as an antitumor compound, especially against MDA-MB231 breast cancer cells.
eng
Mamas - Cáncer
Café
The coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cells
conference output
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URL
https://riuma.uma.es/bitstreams/592b33b0-bf3a-41b4-af75-98f1dfb08d32/download
File
MD5
9cced9c4891c72f03443abc5e79dc129
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application/pdf
Abstract aceptado.pdf
URL
https://riuma.uma.es/bitstreams/765a2b4b-d7c1-44b6-9052-d4034fc905fa/download
File
MD5
0411b5aebe689ae8e1fd22fac816ac5b
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text/plain
Abstract aceptado.pdf.txt