2026-05-28T17:36:16Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/78022026-02-03T12:00:42Zcom_10630_2254col_10630_37959

Sensitivity of polyamine metabolism to glucose deprivation is increased in neuroblastoma cells with N-myc amplification Ruiz-Pérez, M. Victoria Urdiales-Ruiz, José Luis Sánchez-Jiménez, Francisca María Medina-Torres, Miguel Ángel Neuroblastoma Poliaminas - Metabolismo Ornithine-derived polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. Neuroblastoma, the most frequent extra-cranial solid tumor in children, harbors amplification of n-myc oncogene (which enhances polyamine metabolism) in 25% of the cases. In the present communication, the relevance of n-myc amplification in several metabolic features of human neuroblastoma cell lines is studied. A previously unknown linkage between glycolysis impairment and polyamine reduction, related to n-myc amplification, is unveiled. Results show that glycolysis inhibition is able to trigger signaling events leading to the reduction of N-Myc protein levels and subsequent decrease of both ornithine decarboxylase expression and polyamine levels, accompanied by cell cycle blockade preceding cell death. Metabolism-targeted therapies are emerging as new approaches for cancer treatment. New anti-tumor strategies could take advantage of the direct relationship between glucose deprivation and PA metabolism impairment leading to cell death described in the present work, and its apparent dependence on n-myc amplification in the case of neuroblastoma. Combined therapies targeting glucose metabolism and polyamine synthesis could be effective in the treatment of n-myc amplified tumors. 2014-07-10T11:31:01Z 2014-07-10T11:31:01Z 2014-07-10T11:31:01Z 2014-07-10 conference output http://hdl.handle.net/10630/7802 eng Beatson International Cancer Conference "Powering the Cancer Machine" Glasgow (Reino Unido) Julio de 2014 open access