2026-06-01T01:12:16Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/80552026-02-03T12:09:29Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Díaz-Casares, Amelia
author
López-González, Manuel Víctor
author
Peinado-Aragonés, Carlos Antonio
author
Dawid-Milner, Marc Stefan
2014-09-18T12:44:14Z
2014-09-18T12:44:14Z
2014-09-18
http://hdl.handle.net/10630/8055
We have previously demonstrated the functional interaction between the
hypothalamic defence area (HDA) and the medial parabrachial region (mPB) in
the cardiorespiratory response evoked to HDA electrical stimulation (Díaz-
Casares et al., 2009, 2012). The aim of this work is characterise the role of
angiotensin II (AngII) in this interaction.
On spontaneously breathing anaesthetised rats (sodium pentobarbitone,
60mg/kg, n=6), the cardiorespiratory response evoked by electrical stimulation
of the HDA (1ms pulses, 20-50 μA, at 100Hz, 5s) was analysed before and 10
minutes after the microinjection of AngII into the mPB (50pmol, 50nl, 5s).
An increase of heart rate (from 398 ± 13.1 to 430 ± 11.8 bpm, p<0.05) and a
decrease of respiratory rate (from 124 ± 10.7 to 96 ± 10.6 cpm, p<0.05) were
observed after the microinjection of AngII into the mPB. No changes were
observed in mean arterial pressure (from 98 ± 4.5 to 104 ± 4.1 mmHg). The
amplitude of the tachycardia evoked by HDA stimulation decreased after the
microinjection of AngII within the mPB (from 26.8 ± 4.5 to 11.8 ± 3.0 bpm
p<0.01). No changes were observed in the amplitude of the pressor response
and tachypnoea.
These data indicate that AngII receptors from mPB have an important role in
mediating the cardiorespiratory activity in resting conditions. The decrease of
the heart rate component of the defence reaction suggests also its importance
modulating the cardiac component the baroreceptor reflex.
Díaz-Casares A, López-González MV, Peinado-Aragonés CA, Lara JP, González-Barón S and
Dawid-Milner MS. Brain Research 2009; 1279: 58-70.
Díaz-Casares A, López-González MV, Peinado-Aragonés CA, González-Barón S and Dawid-
Milner MS. Autonomic Neurosci. 2012; 169: 124-134.
eng
Angiotensinas
Functional interaction between medial parabrachial region and the hypothalamic defence area: role of angiotensin II
conference output
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Abstract Milan 2014.pdf
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Abstract Milan 2014.pdf.txt