2026-05-31T08:42:23Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/96432026-02-03T12:17:29Zcom_10630_2254col_10630_37959

Risk and protective factors for release in outpatients with schizophrenia Bellido-Estévez, Inmaculada López, C. Bellido Estévez, María Victoria Blanco-Reina, Encarnación Gómez-Luque, A. Esquizofrenia Relapse Schizophrenia Risk factors Protective factors eposter We aim to determine risk and protective factors influencing relapse incidence in outpatient with schizophrenia. A longitudinal, observational study was done with outpatients with schizophrenia (F20) or schizoaffective disorder (F25)(DMS-IV and ICD-10), without hospitalization during the previous 6 months. The patients were consecutively included into the study to received oral (O-A) or long-acting injectable (depot-A) antipsychotics. Clinical stage evolution, compliance, efficacy and safety assessments (including PANSS, CGI-SSI, hospitalization rates, and adverse events) were recorded before and after 6 and 12 months of treatment. Results: 60 outpatients (aged 34.5±8.9, male 73%), 75% schizophrenia and 25% schizoaffective disorder diagnosis, 68.3% fewer than 15 years of schizophrenia evolution, 76.7% fewer than 5 times previous hospitalizations were treated with O-A (41.7%) or depot-A (58.3%) antipsychotics for at least one year. Depot-A treated patients showed a significant higher compliance compared to O-A patients during the all following time, lower PANSS (total, positive and negative) scores and CGI-SSI score (p<0.01), and a delayed relapse incidence and re-hospitalization to more than 1 year in the 48% of patients (relapse % depot/% oral) after 6 months 22.9%/52.0%, and after 12 months 48.6%/4.0%. Conclusion: There were protective factors which delayed relapse incidence in schizophrenia: Use of sustained-release preparations, family support. There were risk factors for occurrence of relapse in schizophrenia: cocaine, heroin and alcohol consumption, absence of family support, greater severity of patients assessed through CGI-SI, male sex, age older than 25 years and long-term evolution of the disorder. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. 2015-04-13T07:54:41Z 2015-04-13T07:54:41Z 2015 2015-04-13 conference output http://hdl.handle.net/10630/9643 https://orcid.org/0000-0002-9362-8635 eng 23th European Congress of Psychiatry (EPA-2015). Vienna, Austria 28 de Marzo, 2015 open access application/pdf