David Ladrón de Guevara-Miranda, Francisco J Pavón, Antonia Serrano, Patricia Rivera, Guillermo Estivill-Torrús, Juan Suárez, Fernando Rodríguez de Fonseca, Luis J Santín, Estela Castilla-Ortega. Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala.

Authors are from Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Psicología, Universidad de Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Spain; Unidad de Gestión Clínica Intercentros de Neurociencias, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospitales Universitarios Regional de Málaga y Virgen de la Victoria, Spain; Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Psicología, Universidad de Málaga, Spain. Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Spain.

Author contact: Luis Javier Santín, luis@uma.es; Estela Castilla Ortega, ecastilla@uma.es

Data_CPPAnxietyBLA
Excel table file containing raw data from Table 2, Figures 1-2 and Supplementary table, divided in sheets, of the related paper.

Table 2: Results of the behavioral assessment in a sample of 16 mice and Pearson’s correlations between behaviors and cocaine-seeking (the CPP-Score) in the test session.  
Figure 1: The ‘Anxiety’ dimension in the EPM predicts cocaine-induced conditioned place preference behavior. 1a Factor scores in Elevated Plus Maze (EPM); 1b Dataset for correlations between EPM 'Anxiolysis' factor score and CPP-Score in test session.
Figure 2: Low and high CPP-expressing mice show structural differences in the basolateral amygdala. 2a EPM 'Anxiolysis' factor score; 2b CPP-Score in habituation and test sessions; 2c CPP-Score in extinction sessions (S1-S12); 2d Total NeuN+ cells in the medial prefrontal cortex (mPFC); 2e Total NeuN+ cells in the basolateral amygdala (BLA); 2f Total TH+ cells in the ventral tegmental area (VTA).
		
Supplementary table: Volume (mm3) of each brain structure and density (cells/mm3) and total number of NeuN+ nuclei (for the mPFC and the BLA) or dopaminergic TH+ neurons (for the VTA) estimated in the right hemisphere of the LowCPP- and the HighCPP-mice.

Groups were coded as:
LowCPP-mice: The five animals with the lowest score in the Conditioned Place Preference test.
HighCPP-mice: The five animals with the highest score in the Conditioned Place Preference test