Listar por autor "Ribelles, Nuria"
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A Carboxylesterase 2 Gene Polymorphism as Predictor of Capecitabine on Response and Time to Progression
Ribelles, Nuria; López-Siles, J; Sánchez-Muñoz, Alfonso
; Sánchez, E; González, E; Sánchez, MJ; Carabantes, F; Sánchez- Rovira, P; Márquez, A; Dueñas, R; Sevilla, I; Alba-Conejo, Emilio[et al.] (Bentham Science Publishers Ltd, 2008)
Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). The ... -
A microRNA signature associated with early recurrence in breast cancer.
Pérez-Rivas, Luis G.; Jerez-Aragonés, José Manuel; Carmona, Rosario; De Luque, Vanessa; Vicioso-Recio, Luis Prudencio; Claros-Díaz, Manuel Gonzalo; Viguera-Mínguez, Enrique; Pajares, Bella; Sánchez-Muñoz, Alfonso; Ribelles, Nuria; Alba-Conejo, Emilio; Lozano-Castro, José[et al.] (PLOS, 2014-03-14)
Recurrent breast cancer occurring after the initial treatment is associated with poor outcome. A bimodal relapse pattern after surgery for primary tumor has been described with peaks of early and late recurrence occurring ... -
A randomized phase II trial of platinum salts in basal-like breast cancer patients in the neoadjuvant setting. Results from the GEICAM/2006-03, multicenter study
Alba-Conejo, Emilio; Chacón, J. L.; Lluc, A.; Antón, A.; Estévez, L.; Cirauqui, B.; Carrasco, E.; Calvo, L.; Seguí, M.A.; Ribelles, Nuria; Álvarez, R.; Sánchez-Muñoz, Alfonso; Sánchez, R.; Lopez Garcia-Asenjo, J.A.; Rodriguez-Martin, C.; Escudero, M.J.; Albanell, J.[et al.] (Springer, 2012-10)
Abstract Chemotherapy remains as the only systemic treatment option available for basal-like breast cancer (BC) patients. Preclinical models and several phase II studies suggested that platinum salts are active drugs in ... -
Clasificación de historias clínicas reales según CIE-10-ES para localización de neoplasias mediante modelos transformers.
Pascual-Mellado, Alejandro; Gallego Donoso, Fernando; Ribelles, Nuria; Jerez-Aragonés, José Manuel; Moreno Barea, Francisco Javier (2024-06-19)
La mayoría de la información clínica almacenada en los sistemas sanitarios españoles se encuentra como texto no estructurado en las historias clínicas electrónicas. La extracción automática de información valiosa contenida ... -
Clinical text classification in Cancer Real-World Data in Spanish
Moreno-Barea, Francisco J.; Mesa, Héctor; Ribelles, Nuria; Alba-Conejo, Emilio; Jerez-Aragonés, José Manuel (2023-06-29)
Healthcare systems currently store a large amount of clinical data, mostly unstructured textual information, such as electronic health records (EHRs). Manually extracting valuable information from these documents is costly ... -
Deciphering HER2 Breast Cancer Disease: Biological and Clinical Implications.
Godoy-Ortiz, Ana; Sánchez-Muñoz, Alfonso; Chica Parrado, María del Rosario; Álvarez-Pérez, Martína; Ribelles, Nuria; Rueda-Domínguez, Antonio; Alba-Conejo, Emilio[et al.] (Frontiers Media, 2019)
The main obstacle for designing effective treatment approaches in breast cancer is the extensive and the characteristic heterogeneity of this tumor. The vast majority of critical genomic changes occurs during breast cancer ... -
Design and implementation of a standard care programme of therapeutic exercise and education for breast cancer survivors
Roldán-Jiménez, Cristina; Pajares, Bella; Ruiz-Medina, Sofía; Trinidad-Fernández, Manuel; González-Sánchez, Manuel; Ribelles, Nuria; García-Almeida, José Manuel; Ríos-López, María José; Alba-Conejo, Emilio; Cuesta-Vargas, Antonio[et al.] (SPRINGER, 2021-08-31)
Background Breast cancer survivors (BCS) face several symptoms and are at higher risk of weight gain following diagnosis. Current literature shows that both exercise and diet play a key role in recovery of BCS. However, ... -
Detection of tumor morphology mentions in clinical reports in Spanish using transformers
López-García, Guillermo; Jerez-Aragonés, José Manuel; Ribelles, Nuria; Alba-Conejo, Emilio; Veredas-Navarro, Francisco Javier (Springer, 2021)
The aim of this study is to systematically examine the performance of transformer-based models for the detection of tumor morphology mentions in clinical documents in Spanish. For this purpose, we analyzed 3 transformer ... -
Different Pathological Complete Response Rates According to PAM50 Subtype in HER2+ Breast Cancer Patients Treated With Neoadjuvant Pertuzumab/Trastuzumab vs. Trastuzumab Plus Standard Chemotherapy: An Analysis of Real-World Data.
Díaz-Redondo, Tamara; Lavado Valenzuela, Rocío; Jiménez-Rodríguez, Begoña; Pascual, Tomás; Gálvez, Fernando; Falcón, Alejandro; Álamo, María del Carmen; Morales-Estévez, Cristina; Amerigo, Marta; Pascual, Javier; Sánchez-Muñoz, Alfonso; González-Guerrero, Macarena; Vicioso-Recio, Luis Prudencio; Laborda-Illanes, Aurora; Ortega-Jiménez, María Victoria; Pérez-Villa, Lidia; Fernández-Martínez, Aranzazu; Chic, Nuria; Jerez-Aragonés, José Manuel; Álvarez-Pérez, Martína; Prat, Aleix; Ribelles, Nuria; Alba-Conejo, Emilio[et al.] (Frontiers Media, 2019)
Double blockade with pertuzumab and trastuzumab combined with chemotherapy is the standard neoadjuvant treatment for HER2-positive early breast cancer. Data derived from clinical trials indicates that the response rates ... -
Efecto de la quimioterapia neoadyuvante en la variación de receptores hormonales, Her2 y Ki67 en pacientes con cáncer de mama
Álvarez-Pérez, Martína; Lavado-Fernández, Ana Isabel; Pérez-Villa, Lidia; Lozano, María José; Jiménez-Rodríguez, Begoña; De Luque, Vanessa; Jiménez-Vista, Álvaro; Ventura, Carmen; Jiménez-Fernández, Ana; Rodrigo-Fernández, Isabel; Ramírez-Tortosa, César; Ribelles, Nuria; Alba-Conejo, Emilio; Vicioso-Recio, Luis Prudencio[et al.] (2016-03-02)
Introducción:Existe controversia respecto al impacto de la quimioterapia en la expresión de marcadores inmunohistoquímicos del cáncer de mama, ya que pueden existir cambios en los marcadores tumorales entre las biopsias ... -
Estudio de factores anatomopatológicos predictivos de respuesta patológica a quimioterapia neoadyuvante y su valor pronóstico en el cáncer de mama
(UMA Editorial, 2017-07-09)La quimioterapia neoadyuvante (QTN) se utiliza cada vez más para conseguir una reducción tumoral que permita una cirugía conservadora y, mediante el grado de respuesta patológica tumoral, poder determinar el pronóstico de ... -
Estudio de factores predictivos de respuesta patológica a quimioterapia neoadyuvante en el cáncer de mama receptores hormonales positivos HER2 negativo
Lavado-Fernández, Ana Isabel; Álvarez-Pérez, Martína; Prieto Cuadra, Juan Daniel; Jiménez-Rodríguez, Begoña; Lozano, María José; De Luque, Vanessa; Jiménez-Vista, Álvaro; Ventura, Carmen; Jiménez-Fernández, Ana; Rodrigo, Isabel; Ramírez, César; Cano, Tatiana; González-Zafra, Virginia; Pérez-Villa, Lidia; Gallego-Domínguez, Elena María; Ortega-Jiménez, María Victoria; Arranz-Salas, Isabel María; Ribelles, Nuria; Alba-Conejo, Emilio; Vicioso-Recio, Luis Prudencio[et al.] (2015-07-02)
La quimioterapia neoadyuvante (QTN) se utiliza cada vez más para conseguir una reducción tumoral que permita una cirugía conservadora y, mediante el grado de respuesta patológica tumoral, determinar el pronóstico de las ... -
Explainable clinical coding with in-domain adapted transformers
López-García, Guillermo; Jerez-Aragonés, José Manuel; Ribelles, Nuria; Alba-Conejo, Emilio; Veredas-Navarro, Francisco Javier (Elsevier, 2023)
Background and Objective: Automatic clinical coding is a crucial task in the process of extracting relevant in-formation from unstructured medical documents contained in Electronic Health Records (EHR). However, most of ... -
Factors associated with upper limb function in breast cancer survivors
Roldán-Jiménez, Cristina; Martín-Martín, Jaime; Pajares, Bella; Ribelles, Nuria; Alba-Conejo, Emilio; Cuesta-Vargas, Antonio[et al.] (Wiley Online Library, 2023-02)
Background: Breast cancer survivors may have side effects from treatment, such as impaired upper limb function after surgery, which may be affected by a range of factors. Objective: To analyze the association between upper ... -
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer.
Sánchez-Muñoz, Alfonso; Gallego-Domínguez, Elena María; De Luque, Vanessa; Pérez-Rivas, Luis G.; Vicioso-Recio, Luis Prudencio; Ribelles, Nuria; Lozano-Castro, José; Alba-Conejo, Emilio[et al.] (Springer Nature, 2010-04-13)
Background: Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal ... -
Machine learning and natural language processing (NLP) approach to predict early progression to first-line treatment in real-world hormone receptor-positive (HRþ)/HER2-negative advanced breast cancer patients.
Ribelles, Nuria; Jerez-Aragonés, José Manuel; Rodríguez-Brazzarola, Pablo; Jiménez-Rodríguez, Begoña; Díaz-Redondo, Tamara; Mesa, Héctor; Márquez, Antonia; Sánchez-Muñoz, Alfonso; Pajares, Bella; Carabantes, Francisco; Bermejo-Pérez, María José; Villar, Ester; Domínguez-Recio, María Emilia; Saez-Lara, Enrique; Gálvez Carvajal, Laura; Godoy-Ortiz, Ana; Franco, Leónardo; Ruiz-Medina, Sofía; López, Irene; Alba-Conejo, Emilio[et al.] (Elsevier, 2021)
Background: CDK4/6 inhibitors plus endocrine therapies are the current standard of care in the first-line treatment of HRþ/HER2-negative metastatic breast cancer, but there are no well-established clinical or molecular ... -
Named Entity Recognition for De-identifying Real-World Health Records in Spanish.
López-García, Guillermo; Moreno-Barea, Francisco J.; Mesa, Héctor; Jerez-Aragonés, José Manuel; Ribelles, Nuria; Alba-Conejo, Emilio; Veredas-Navarro, Francisco Javier[et al.] (Springer Nature, 2023)
A growing and renewed interest has emerged in Electronic Health Records (EHRs) as a source of information for decision-making in clinical practice. In this context, the automatic de-identification of EHRs constitutes an ... -
Named entity recognition for de-identifying Spanish electronic health records
Moreno-Barea, Francisco J.; López-García, Guillermo; Mesa, Héctor; Ribelles, Nuria; Alba-Conejo, Emilio; Jerez-Aragonés, José Manuel; Veredas-Navarro, Francisco Javier[et al.] (Elsevier, 2025-02)
Background and objectives: There is an increasing and renewed interest in Electronic Health Records (EHRs) as a substantial information source for clinical decision making. Consequently, automatic de-identification of EHRs ... -
Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index.
Ribelles, Nuria; Jerez-Aragonés, José Manuel; Pajares, Bella; Vicioso-Recio, Luis Prudencio; Jiménez-Rodríguez, Begoña; De Luque, Vanessa; Franco, Leónardo; Gallego-Domínguez, Elena María; Márquez, Antonia; Álvarez, Martina; Sánchez-Muñoz, Alfonso; Pérez-Rivas, Luis G.; Alba-Conejo, Emilio; Ribelles, Nuria[et al.] (BMC, 2013-10-22)
Recurrence risk in breast cancer varies throughout the follow-up time. We examined if these changes are related to the level of expression of the proliferation pathway and intrinsic subtypes. Results: Luminal A displayed ... -
Serum protein levels following surgery in breast cancer patients: A protein microarray approach
Pérez-Rivas, Luis G.; Jérez, J.M.; Fernández-De Sousa, C.E.; De Luque, Vanessa; Quero, C.; Pajares, Bella; Franco, L.; Sánchez-Muñoz, Alfonso; Ribelles, Nuria; Alba-Conejo, Emilio[et al.] (Spandidos Publications, 2012-07)
Surgery is the primary treatment for non-metastatic breast cancer. However, the risk of early recurrence remains after surgical removal of the primary tumor. Recurrence is suggested to result from hidden micrometastatic ...