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Listar por autor "Choi, Bo-Ran"
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GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein
Nakamura, Mai; Li, Yuhan; Choi, Bo-Ran; Matas-Rico, Elisa; Troncoso, Juan; Takahashi, Chiaki; Sockanathan, Shanthini; Troncoso[et al.] (American Association for the Advancement of Science, 2021-03)A disintegrin and metalloprotease 10 (ADAM10) is the α-secretase for amyloid precursor protein (APP). ADAM10 cleaves APP to generate neuroprotective soluble APPα (sAPPα), which precludes the generation of Aβ, a defining ...