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Effect of the protein corona formation on antibody functionalized liquid lipid nanocarriers
Navarro-Marchal, Saúl; Martín Contreras, Marina; Castro-Santiago, David; del Castillo-Santaella, Teresa; Graván, Pablo; Jódar-Reyes, Ana Belén; Marchal, Juan Antonio; Peula-García, José Manuel[et al.] (MDPI, 2023-11)The main aim of this study is to report basic knowledge on how a protein corona (PC) could affect or modify the way in which multifunctionalized nanoparticles interact with cells. With this purpose, we have firstly optimized ... -
Formulation, colloidal characterization, and in vitro biological effect of BMP-2 loaded PLGA nanoparticles for bone regeneration
del Castillo-Santaella, Teresa; Ortega-Oller, Inmaculada; Padial-Molina, Miguel; O'valle, Francisco; Galindo-Moreno, Pablo; Jódar-Reyes, Ana Belén; Peula-García, José Manuel[et al.] (MDPI, 2019-08)Nanoparticles (NPs) based on the polymer poly (lactide-co-glycolide) acid (PLGA) have been widely studied in developing delivery systems for drugs and therapeutic biomolecules, due to the biocompatible and biodegradable ... -
Interaction of surfactant and protein at the O/W interface and its effect on colloidal and biological properties of polymeric nanocarriers.
del Castillo-Santaella, Teresa; Peula-García, José Manuel; Maldonado-Valderrama, Julia; Jódar-Reyes, Ana Belén (Elsevier B.V., 2018-09-29)Hypothesis: The use of polymer-based surfactants in the double-emulsion (water/oil/water, W/O/W) solventevaporation technique is becoming a widespread strategy for preparing biocompatible and biodegradable polymeric ...