Listar por autor "Chun, Jerold"
Mostrando ítems 1-14 de 14
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai-Amal, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Absence of LPA1 signaling results in defective cortical development
Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Matas-Rico, Elisa; Rodríguez de Fonseca, Fernando; Chun, Jerold; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen; De-Diego-Barbado, Isabel; Del Arco-Herrera, Ignacio; Fernández-Llebrez, Pedro[et al.] (Oxford academy, 2008-04)
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, María del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Caramés-Tejedor, José María; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
Matas-Rico, Elisa; Garcia Diaz, Beatriz; Llebrez Zayas, Pedro; López-Barroso, Diana; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen; Smith-Fernández, José Aníbal; Téllez-Santana, Teresa; Redondo-Bautista, Maximino; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Elsevier, 2008)
Neurogenesis persists in certain regions of the adult brain including the subgranular zone of the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to learning, stress and modulation ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
Castilla-Ortega, María Estela; Sánchez-López, Jorge; Hoyo-Becerra, Carolina; Matas-Rico, Elisa; Zambrana-Infantes, Emma; Chun, Jerold; Rodríguez de Fonseca, Fernando; Pedraza-Benítez, María del Carmen; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (Elsevier, 2010-07)
Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, Cristina; Martínez-Losa, Magdalena; Matas-Rico, Elisa; Castilla-Ortega, María Estela; Zambrana-Infantes, Emma; Gómez-Conde, Ana Isabel; Sánchez-Salido, Lourdes; Ladrón de Guevara-Miranda, David; Pedraza-Benítez, María del Carmen; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodríguez de Fonseca, Fernando; Álvarez Dolado, Manuel; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2021-04-01)
Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex
Garcia Diaz, Beatriz; Riquelme, Raquel; Varela Nieto, Isabel; Jiménez-Lara, Antonio Jesús; De-Diego-Barbado, Isabel; Gómez-Conde, Ana Isabel; Matas-Rico, Elisa; Aguirre-Gómez, José Ángel; Chun, Jerold; Pedraza-Benítez, María del Carmen; Santín-Núñez, Luis Javier; Fernández Fernández, Óscar; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2014)
Lysophosphatidic acid (LPA) is an intercellular signaling lipid that regulates multiple cellular functions, acting through specific G-protein coupled receptors (LPA1–6). Our previous studies using viable Malaga variant ... -
Role of the LPA1 receptor in mood and emotional regulation
Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2015-09-16)
Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román D.; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; García-Fernández, María Inmaculada; Chun, Jerold; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-17)
Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ... -
Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach
Moreno-Fernández, Román D.; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, María Inmaculada; Chun, Jerold; Pedraza-Benítez, María del Carmen; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (2018-07-16)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ... -
The limbic brain under stress: a role for the LPA1 receptor
Moreno-Fernández, Román D.; Tabbai-Amal, Sara; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (UNED, 2017-07)
Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ... -
What role does the LPA1 receptor play in regulating emotional-like behaviours?
Pedraza-Sánchez-López, J.; Castilla-Ortega, María Estela; Rosell-del-Valle, Cristina; Moreno-Fernández, Román D.; Zambrana-Infantes, Emma; García-Fernández, María Inmaculada; Rodriguez-de-Fonseca, Fernando; Chun, Jerold; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (2015-07-24)
The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been proposed that this receptor has a role ...