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SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease
Trujillo-Estrada, Laura Isabel; Vanderklish, Peter; Minh Thu Nguyen, Marie; Kuang, Run Rong; Nguyen, Caroline; Huynh, Eric; da Cunha, Celia; Ibarra Javonillo, Dominic; Forner, Stefania; Martini, Alessandra C.; Sarraf, Stella; Simmon, Vicent; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Elsevier, 2021-10)Alzheimer’s disease (AD) is conceptualized as a synaptic failure disorder in which loss of glutamatergic synapses is a major driver of cognitive decline. Thus, novel therapeutic strategies aimed at regenerating synapses ...