Listar por autor "Moreno-Gonzalez, Ines"
Mostrando ítems 1-5 de 5
-
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
(Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer's Disease
(Sage Journals, 2019)Cerebrospinal fluid (CSF) outflow from the brain occurs through absorption into the arachnoid villi and, more predominantly, through meningeal and olfactory lymphatics that ultimately drain into the peripheral lymphatics. ... -
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
(Rockefeller University PRess, 2017)Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ... -
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Moreno-Gonzalez, Ines; Estrada, Lisbell D; Sánchez-Mejías, Elisabeth
; Soto, Claudio (Macmillan Publishers Limited, 2013-02)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(Cell Death and Differentiation, 2020)Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ...