- RIUMA Principal
- Listar por autor
Listar por autor "Perlman, Stanley"
Mostrando ítems 1-5 de 5
-
Identification of the mechanisms causing reversion to virulence in an attenuated SARS-CoV for the design of a genetically stable vaccine
Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Perlman, Stanley; Enjuanes, Luis[et al.] (Public Library of Science, 2015)A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the ... -
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
DeDiego, Marta L.; Nieto-Torres, Jose Luis; Regla-Nava, Jose Angel; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis[et al.] (ASM Journals, 2014)Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated ... -
Role of severe acute respiratory syndrome Coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis
Castaño-Rodriguez, Carlos; Honrubia, José M.; Gutiérrez-Álvarez, Javier; DeDiego, Marta L.; Nieto-Torres, Jose Luis; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Verdiá-Báguena, Carmina; Queralt-Martín, María; Kochan, Grazyna; Perlman, Stanley; Aguilella, Vicente M; Sola, Isabel; Enjuanes, Luis[et al.] (American Society for Microbiology, 2018)Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe ... -
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.
DeDiego, Marta L.; Nieto-Torres, José Luis; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel; Álvarez, Enrique; Oliveros, Juan Carlos; Zhao, Jincun; Fett, Craig; Perlman, Stanley; Enjuanes, Luis[et al.] (PLOS, 2011)Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected ... -
Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates
Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis; DeDiego, Marta L.[et al.] (ASM Journals, 2015)Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease with a mortality rate of 10%. A mouse-adapted SARS-CoV (SARS-CoV-MA15) lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated ...