Listar por autor "López-Ávalos, María Dolores"
Mostrando ítems 1-20 de 23
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro
; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Mateos-Grondona, Jesús; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)
Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; León-Rodríguez, Ana[et al.] (Wiley Periodicals, LLC, 2021-07)
A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Anxiety‑like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase.
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (Springer Nature, 2022-07-08)
Short-term behavioral alterations are associated with infection and aid the recovery from sickness. However, concerns have raised that sustained behavioral disturbances after acute neuroinflammation could relate to ... -
Chronic ethanol induces morpohological changes on hippocampal microglia, which are reverted by pharmacological blockade of faah with urb597
Fernández-Arjona, María del Mar; Rivera, Patricia; Silva-Peña, Daniel; Blanco, Eduardo; Vargas, Antonio; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2018-11-29)
Here, we evaluated the pharmacological effects of fatty-acid amide-hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg), oleoylethanolamide (OEA, 10 mg/kg), arachidonoylethanolamide (AEA, 10 mg/kg), the CB1 receptor agonist ACEA ... -
Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola
Mancera Romero, Juan Miguel; López-Ávalos, María Dolores (2019-12-20)
Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola En la bahía de Cádiz existe una consolidada actividad de acuicultura, con un importante ... -
Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)
It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
Enhanced stress response in rats that suffered acute neuroinflammation induced by neuraminidase three months before
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (2022)
Microglial cells are protagonists in neuroinflammatory processes and their activation is a notorious feature of such events. In acute inflammation, microglial cells return to their basal surveillant state in few days. ... -
FGF2, but not EGF, Induces multiciliated ependymal cells to dedifferentiate and adopt radial glial features in vitro
Mateos-Grondona, Jesús; Granados-Durán, Pablo; Navarro Dueñas, Isabel; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2014-07-21)
Multiciliated ependymal cells form an epithelium lining most of the ventricular cavities of vertebrates brain. Although considered postmitotic and completely differentiated, ependymal cells maintain some phenotypic ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)
Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Wiley, 2022-05-22)
Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Long-term reprogramming of primed microglia after moderate inhibition of CSF1R signaling.
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Marín Wong, Sonia; López-Aranda, Manuel Francisco; López-Ávalos, María Dolores (Wiley, 2024)
In acute neuroinflammation, microglia activate transiently, and return to a resting state later on. However, they may retain immune memory of such event, namely priming. Primed microglia are more sensitive to new stimuli ... -
Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Frontiers Media, 2022-07-28)
Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune ... -
Microglia activated by microbial neuraminidase contributes to ependymal cell death.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; López-Ávalos, María Dolores; Mateos-Grondona, Jesús (Springer Nature, 2021-03-23)
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. ... -
Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors.
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Springer Nature, 2019-12-02)
Background: Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administration ... -
Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Frontiers Media, 2019-10-25)
Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia have been described: one considered as a resting/surveillant state in which cells have a highly branched morphology, and another ... -
Morphological traits of surveillant/activated microglia during an experimentally induced acute neuroinflammatory process
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro (2016-07-12)
Several studies show that morphological changes of microglia over the course of inflammation are tightly coupled to function. However the progressive transformation into activated microglia is poorly characterized. AIMS: ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Carrillo-Pinzón, Cristóbal; Fernández-Llebrez, Pedro (2017-10-04)
Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (2021)
An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)
The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
Papel de la microglía en la neuroinflamación generada mediante neuraminidasa
(UMA Editorial, 2017-12-19)Está ampliamente aceptado que en algunas ocasiones la neuroinflamación es un proceso previo al desarrollo de enfermedades neurodegenerativas y que la microglía juega un papel clave en el desarrollo de la misma. En particular, ...