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Listar por autor "López-Ávalos, María Dolores"
Mostrando ítems 1-13 de 13
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes, Manuel; Pérez-Martín, Margarita; [et al.] (2014-07-14)Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Chronic ethanol induces morpohological changes on hippocampal microglia, which are reverted by pharmacological blockade of faah with urb597
Fernández-Arjona, María del Mar; Rivera, Patricia; Silva-Peña, Daniel; Blanco, Eduardo; Vargas, Antonio; [et al.] (2018-11-29)Here, we evaluated the pharmacological effects of fatty-acid amide-hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg), oleoylethanolamide (OEA, 10 mg/kg), arachidonoylethanolamide (AEA, 10 mg/kg), the CB1 receptor agonist ACEA ... -
Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola
Mancera Romero, Juan Miguel; López-Ávalos, María Dolores (2019-12-20)Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola En la bahía de Cádiz existe una consolidada actividad de acuicultura, con un importante ... -
Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernandez-Arjona, Mar; Mateos-Grondona, Jesus; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
FGF2, but not EGF, Induces multiciliated ependymal cells to dedifferentiate and adopt radial glial features in vitro
Grondona, Jesús M; Granados-Durán, Pablo; Navarro Dueñas, Isabel; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2014-07-21)Multiciliated ependymal cells form an epithelium lining most of the ventricular cavities of vertebrates brain. Although considered postmitotic and completely differentiated, ependymal cells maintain some phenotypic ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona, Jesús M; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Grondona, Jesús M; López-Ávalos, María Dolores (Wiley, 2022-05-22)Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Morphological traits of surveillant/activated microglia during an experimentally induced acute neuroinflammatory process
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesus; Fernández-Llebrez, Pedro (2016-07-12)Several studies show that morphological changes of microglia over the course of inflammation are tightly coupled to function. However the progressive transformation into activated microglia is poorly characterized. AIMS: ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernandez-Arjona, Mar; López-Ávalos, María Dolores; Grondona, Jesús M; Carrillo-Pinzon, Cristobal; Fernández-Llebrez, Pedro (2017-10-04)Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, Maria del Carmen; Mateos-Grondona, Jesus; López-Ávalos, María Dolores (2021)An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Grondona, Jesús M; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
Papel de la microglía en la neuroinflamación generada mediante neuraminidasa
Fernandez Arjona, Maria Del Mar (UMA Editorial, 2017-12-19)Está ampliamente aceptado que en algunas ocasiones la neuroinflamación es un proceso previo al desarrollo de enfermedades neurodegenerativas y que la microglía juega un papel clave en el desarrollo de la misma. En particular, ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Grondona, Jesús M; [et al.] (2015-05-27)Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...