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Listar por autor "López-Ávalos, María Dolores"
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Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernandez-Arjona, Mar; Grondona, Jesus; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona JM; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernandez-Arjona, Mar; López-Ávalos, María Dolores; Grondona, Jesus; Carrillo-Pinzon, Cristobal; Fernández-Llebrez, Pedro (2017-10-04)Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Grondona, Jesús M; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ...