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Listar por autor "López-Romero, Juan Manuel"
Mostrando ítems 1-15 de 15
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Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernandez, Maria; Lucena-Serrano, Cristina; Rivera-Ramirez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Desarrollo de un prototipo simulador del tracto gastrointestinal mediante reactores químicos automatizados
Rivas Montoya, Ernesto (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)El prototipo descrito en esta Tesis Doctoral se emplea para realizar la simulación in vitro del tracto gastrointestinal. Esta simulación se lleva a cabo en las tres fases que se describen a continuación: simulación de ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Carrillo Fernández, Paloma; [et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Lipid and Janus nanoparticles for active delivery
López-Romero, Juan Manuel (2014-06-12)The following synthesis is based on the paper „Production of large quantities of „Janus“ nanoparticles using wax-in-water emulsions“ published by Ravaine et al.[1]In two beakers, 0.2 g of the synthesized silica particles ... -
Nanopartículas híbridas Fe3O4@pNIPAM y Ag2S/Ag para aplicaciones en nanomedicina
Ortega Rodríguez, Alicia (UMA Editorial, 2022)Esta Tesis Doctoral se engloba dentro del ámbito de la nanomedicina mediante el desarrollo y la caracterización de nanopartículas con potencial uso biomédico para el diagnóstico y tratamiento de enfermedades. Por un ... -
Nanopartículas metalo-orgánicas: síntesis, caracterización y aplicación a la vehiculización de Paclitaxel, 5-Fluorouracilo y Doxorrubicina
Moscoso Reina, Ana Isabel (UMA Editorial, 2019-11)La síntesis y optimización de sistemas de nanopartículas en medicina muestra interés debido a las características que presentan: i) son sensibles a estímulos externos, como el pH, la temperatura, la luz etc. y ii) la alta ... -
Síntesis y caracterización de nanopartículas metalopoliméricas sensibles a ph y temperatura. aplicación a la mejora catalítica de nanopartículas metálicas
Doña Flores, Manuel (UMA Editorial, 2021-03-10)Con esta Tesis Doctoral se han conseguido dos grandes objetivos científicos, por un lado, la preparación de microgeles huecos que pueden ser empleados como microcontenedores con capacidad de acumulación y liberación de ... -
Study and characterization of modified silicon surfaces with organic molecules
Valpuesta-Fernandez, Maria; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ... -
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines
Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ... -
Synthesis of bioactive compounds. Studies of their attachment to nanoparticles
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ... -
Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles
ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; [et al.] (IOAP-MPDI, 2022-05-31)The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ... -
Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment
ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was ... -
Tripod-shaped penta (p-phenylene)s for the functionalization of silicon surfaces
Sánchez-Molina, María Sánchez-Molina,; Contreras-Cáceres, Rafael; Díaz, Amelia; Valpuesta-Fernandez, Maria; López-Romero, Juan Manuel (2016-03-31)In order to obtain nanostructured thin films to be used in biosensor devices, several chemical functionalization methods have been developed, such as Click chemistry or Suzuki carbon-carbon coupling reactions on surfaces.1 ... -
Tripodal p-phenylene Molecules: Synthesis and Immobilization on Gold and Silicon Substrates
Sanchez Molina, Maria (Uma Editorial, 2019-10)La principal hipótesis de este trabajo de Tesis consiste en que la máxima efectividad de cualquier dispositivo se logrará con la estructuración a nivel molecular de las superficies. Por ello es necesario disponer de métodos ...