• An ecological model of invasion and metastasis 

      Serrano, José J.; Urdiales, José L.; Medina, Miguel Ángel; Montañez, Raúl (2017-08-29)
      It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ...
    • El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo 

      Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)
      Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ...
    • Antitumor and antiangiogenic potential of solomonamide synthesis intermediates 

      Carrilo, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)
      In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ...
    • CRISPR for Bio-Art? 

      Medina, Miguel Ángel (2018-06-25)
      This communication will explain the biotechnological procedure of gene edition based on CRISPR and will discuss the implications that its use could have in the bioartistic praxis. A metaphorical figure has been produced ...
    • Estudios de preferencia metabólica en células del “microambiente angiogénico” 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ...
    • Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention 

      Medina, Miguel Ángel; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales, José L.; [et al.] (2017-08-29)
      The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ...
    • Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2017-10-31)
      The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ...
    • Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis 

      García-Vilas, Javier A.; Quesada, Ana R.; Medina, Miguel Ángel (Elsevier, 2017-04)
      The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ...
    • Identification and characterization of new anti-angiogenic compounds from natural sources 

      Carrillo, Paloma; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2017-07-21)
      The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ...
    • Interplay between glucose and palmitate uptake in breast carcinoma in vitro 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2018-07-17)
      One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ...
    • kpath: An example of metabolic pathway data integration using Linked Data 

      Navas-Delgado, Ismael; García-Godoy, Maria Jesús; López-Camacho, Esteban; Ribinski, Maciej; Reyes-Palomares, Armando; [et al.] (2016)
      The main databases related to metabolic pathways, such as Kegg, Brenda, Reactome and Biocyc, provide partially interlinked data on metabolic pathways. This limitation only allows independent searches to retrieve cross-database ...
    • La enseñanza del metabolismo: retos y oportunidades 

      Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; [et al.] (2017-12)
      Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ...
    • Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells? 

      Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2019-04-24)
      Metabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ...
    • Learning contract, co-operative and flipped learning as useful tools for studying metabolism 

      Martínez Poveda, Beatriz; García Ponce, Ángel Luis; Blanco López, Ángel; Rodriguez-Quesada, Ana Maria; Suarez-Marin, Maria Fernanda; [et al.] (2018-06-25)
      Undergraduate students in Biology identify Metabolic Biochemistry as a particularly difficult subject. This is due to the fact that students need to interconnect properly all the contents of its syllabus throughout their ...
    • Libro de actas del Workshop Internacional Metabolic Reprogramming as a Target for Cancer and Other Diseases 

      Martínez Poveda, Beatriz; Guadix, Juan Antonio; Medina, Miguel Ángel (2018-12-17)
      Este libro sobre el Workshop Internacional Metabolic Reprogramming as a Target for Cancer and Other Diseases se ha publicado con el apoyo económico de los fondos para difusión y divulgación del Proyecto del Plan Estatal ...
    • Marine sponge as a source of antiangiogenic compounds. The case of aeroplysinin-1 

      Quesada, AR; Martínez-Poveda, B; Rodríguez-Nieto, S; Medina, Miguel Ángel (2014-04-02)
      The vast majority of the natural compounds that have been previously described as inhibitors of angiogenesis have been isolated from plants and terrestrial microorganisms, mainly due to their higher availability and because ...
    • Metabolic preference studies in cells of the tumor microenvironment 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ...
    • Network perspective of histamine related diseases 

      Moya-García, Aurelio A.; Rodríguez-López, Rocío; Medina, Miguel Ángel; Sánchez-Jiménez, Francisca (2017-08-29)
      Histamine is the most pleiotropic biogenic amine. Produced and stored by a limited set of cells—histaminergic neurons, enterochromaffin-like cells, and mast cells—it broadcasts intercellular communication signals to a wide ...
    • Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway 

      García-Caballero, Melissa; Blacher, S.; Pauper, J.; Quesada, Ana R.; Medina, Miguel Ángel; [et al.] (Wiley, 2016)
      BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ...
    • Role of glucose, glutamine and palmitate in endothelial and tumor metabolism 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-12-22)
      Glucose and glutamine are the major sources of energy for mammalian cells. In tumors, Warburg effect and glutaminolysis have been largely studied. On the other hand, a major role of glucose in angiogenesis has been ...