Listar por autor "Medina-Torres, Miguel Ángel"
Mostrando ítems 1-20 de 95
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A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María
; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Cárdenas, Casimiro (MDPI, 2023-07-27)
Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed ... -
AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2014-09-16)
In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, José Luis; Medina-Torres, Miguel Ángel; Montañez, Raúl (2017-08-29)
It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Análisis de compuestos naturales candidatos a fármacos por su actividad antitumoral, antiinflamatorio o antiangiogénico
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)El término cáncer, enfermedad neoplásica o enfermedad tumoral, integra a una gran diversidad de condiciones patológicas con muy distintas etiologías, desarrollo y pronóstico. En la evolución de un tumor o progresión tumoral ... -
El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2016-10-03)
Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ... -
Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
Bravo-Ruiz, Inés; Bernal, Manuel; Manrique-Poyato, Maria Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Castilla, Laura; Martínez-Póveda, Beatriz Amparo[et al.] (43 Congreso Anual SEBBM, 2021)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included ... -
Antiangiogenic potential of an anthraquinone metabolite isolated from a marine fungus.
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2023)
The potential of marine organisms to yield bioactive molecules is vast and largely unexplored. Significantly, certain bioactive compounds derived from the marine environment have already received approval as anticancer ... -
Antiangiogenic potential of an olive oil extract: insights from a proteomic study
Marrero Capitán, Ana Dácil; Cárdenas García, Casimiro; Castilla, Laura; Ortega Vidal, Juan; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ACS, 2024)
Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects ... -
Antioxidant potential of an anthraquinone metabolite isolated from a marine fungus.
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2023)
Marine ecosystem is a fruitful source of many pharmacologically active. In particular, a number of marine anthraquinones and their derivatives, have been studied for their potential as anticancer and antimetastatic agents, ... -
Antitumor activity of Toluquinol
Torres-Vargas, José Antonio; Sounni, Nor Eddine; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María; García-Caballero, Melissa (2022)
Colorectal cancer (CRC) is the third most common cause of cancer mortality worldwide, with more than 1.85 million cases and 850.000 deaths annually1. Currently, the primary methods for treating CRC are surgery, radiotherapy ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
García-Ponce, Ángel Luis; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Blanco-López, Ángel; Rodríguez-Quesada, Ana María[et al.] (ACS Publications, 2021)
Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero Capitán, Ana Dácil; Castilla, Laura; Espartero Sánchez, José Luis; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero Sánchez, José Luis; Madrona, Andrés; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (Royal Society of Chemistry, 2018)
Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ...