Listar por autor "Medina-Torres, Miguel Ángel"
Mostrando ítems 1-20 de 77
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AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel (2014-09-16)
In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, José Luis; Medina-Torres, Miguel Ángel; Montañez, Raúl (2017-08-29)
It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Análisis de compuestos naturales candidatos a fármacos por su actividad antitumoral, antiinflamatorio o antiangiogénico
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)El término cáncer, enfermedad neoplásica o enfermedad tumoral, integra a una gran diversidad de condiciones patológicas con muy distintas etiologías, desarrollo y pronóstico. En la evolución de un tumor o progresión tumoral ... -
El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2016-10-03)
Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
Bravo-Ruiz, Inés; Bernal, Manuel; Manrique-Poyato, Maria Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Castilla, Laura; Martínez-Póveda, Beatriz Amparo[et al.] (43 Congreso Anual SEBBM, 2021)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included ... -
Antiangiogenic potential of an anthraquinone metabolite isolated from a marine fungus.
Vidal Valenzuela, Isabel; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2023)
The potential of marine organisms to yield bioactive molecules is vast and largely unexplored. Significantly, certain bioactive compounds derived from the marine environment have already received approval as anticancer ... -
Antioxidant potential of an anthraquinone metabolite isolated from a marine fungus.
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2023)
Marine ecosystem is a fruitful source of many pharmacologically active. In particular, a number of marine anthraquinones and their derivatives, have been studied for their potential as anticancer and antimetastatic agents, ... -
Antitumor activity of Toluquinol
Torres-Vargas, José Antonio; Sounni, Nor Eddine; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María; García-Caballero, Melissa (2022)
Colorectal cancer (CRC) is the third most common cause of cancer mortality worldwide, with more than 1.85 million cases and 850.000 deaths annually1. Currently, the primary methods for treating CRC are surgery, radiotherapy ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (Royal Society of Chemistry, 2018)
Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado-Martín, Belén; Medina-Torres, Miguel Ángel (2020-09-22)
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sánchez, Lilian B.; Marí-Beffa, Manuel; Carrillo Fernández, Paloma; Medina-Torres, Miguel Ángel; Díaz-Cuenca, Aránzazu (2018-10-19)
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more ... -
Creatividad en la ciencia, creatividad de la ciencia
Medina-Torres, Miguel Ángel (Universidad de Málaga, 2006)
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CRISPR for Bio-Art?
Medina-Torres, Miguel Ángel (2018-06-25)
This communication will explain the biotechnological procedure of gene edition based on CRISPR and will discuss the implications that its use could have in the bioartistic praxis. A metaphorical figure has been produced ...