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Listar por autor "Medina, Miguel ángel"
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AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Quesada, Ana R.; Medina, Miguel Ángel (2014-09-16)In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, Jose Luis; Medina, Miguel Ángel; Montañez, Raúl (2017-08-29)It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Análisis de compuestos naturales candidatos a fármacos por su actividad antitumoral, antiinflamatorio o antiangiogénico
García-Vilas García, Javier Alejandro (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)El término cáncer, enfermedad neoplásica o enfermedad tumoral, integra a una gran diversidad de condiciones patológicas con muy distintas etiologías, desarrollo y pronóstico. En la evolución de un tumor o progresión tumoral ... -
El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernandez, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Biología de Sistemas... ¿qué biología de sistemas?
Medina, Miguel Ángel (2011) -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
García-Ponce, Ángel Luis; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina, Miguel ángel; Blanco-López, Ángel; [et al.] (ACS Publications, 2021)Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Quesada, Ana R.; [et al.] (2020-09-22)The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina, Miguel Ángel; [et al.] (Royal Society of Chemistry, 2018)Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado, Belén; Medina, Miguel Ángel (2020-09-22)Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sánchez, Lilian B.; Mari-Beffa, Manuel; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Díaz-Cuenca, Aránzazu (2018-10-19)The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more ... -
Creatividad en la ciencia, creatividad de la ciencia
Medina, Miguel Ángel (Universidad de Málaga, 2006) -
CRISPR for Bio-Art?
Medina, Miguel Ángel (2018-06-25)This communication will explain the biotechnological procedure of gene edition based on CRISPR and will discuss the implications that its use could have in the bioartistic praxis. A metaphorical figure has been produced ... -
El análogo de las estrigolactonas GR-24 induce cambios en el citoesqueleto de células tumorales y endoteliales y modula su balance rédox
Torres-Vargas, José Antonio; Martínez-Poveda, Beatriz; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2018-12-12)Las estrigolactonas son hormonas vegetales con estructura terpenoide, implicadas en el control de una serie de procesos que incluyen la inhibición de la ramificación de la raíz y el brote. Recientemente, se ha descrito el ... -
Estudios de preferencia metabólica en células del “microambiente angiogénico”
Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales-Ruiz, Jose Luis; [et al.] (2017-08-29)The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
Marrero, Ana Dácil; Martínez-Poveda, Beatriz; Castillo, Laura; Gallardo, Elena; Espartero, José L.; [et al.] (2018-09-19)Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Carrillo Fernández, Paloma; [et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis
Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2017-10-31)The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Mari-Beffa, Manuel (2018-10-19)Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ...