Listar por autor "Perkins, James Richard"
Mostrando ítems 1-5 de 5
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Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP.
Rojano, Elena; García-Ranea, Juan Antonio
; Perkins, James Richard (Springer, 2016-06-06)
Almost 90 % of disease-associated genetic variants found using genome wide association studies (GWAS) are located in non-coding regions of the genome. Such variants can affect phenotype by altering important regulatory ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
Monterde, Beatriz; Rojano Rivera, María Elena; Córdoba Caballero, José; Seoane Zonjic, Pedro; Perkins, James Richard; Medina-Torres, Miguel Ángel; García-Ranea, Juan Antonio[et al.] (Elsevier, 2023)
Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
Regulatory variants: from detection to predicting impact.
(Oxford Academic, 2018-06-08)Variants within non-coding genomic regions can greatly affect disease. In recent years, increasing focus has been given to these variants, and how they can alter regulatory elements, such as enhancers, transcription factor ... -
Study of comorbidity networks among pathological phenotypes in patients with rare genomic disorders
(UMA Editorial, 2022)Durante el desarrollo de esta tesis doctoral se han utilizado aproximaciones de la biología de sistemas para estudiar y caracterizar las relaciones comórbidas entre fenotipos relacionados con enfermedades genéticas raras ... -
Transcriptional profiling of dendritic cells in a mouse model of food-antigen induced anaphylaxis reveals the upregulation of multiple immune-related pathways.
Rodríguez, María José; Palomares, Francisca; Bogas, Gador; Torres-Jaén, María Josefa; Díaz-Perales, Araceli; Rojo, Javier; Plaza Serón, María del Carmen; Rodríguez-Nogales, Alba; Orengo, Christine A.; Mayorga, Cristobalina; Perkins, James Richard[et al.] (Wiley, 2018-10-20)
Scope Much of our knowledge about gene expression during anaphylaxis comes from candidate gene studies. Despite their potential role, expression changes in dendritic cells (DCs) have not been studied in this context using ...