Listar por autor "Muñoz-Chápuli-Oriol, Ramón"
Mostrando ítems 1-15 de 15
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Cardiomyocyte-Specific Wt1 Is Involved in Cardiac Metabolism and Response to Damage.
Díaz del Moral, Sandra; Benaouicha, Maha; Villa del Campo, Cristina; Torres, Miguel; Wagner, Nicole; Wagner, Kay-Dietrich; Muñoz-Chápuli-Oriol, Ramón
; Carmona-Mejías, Rita María[et al.] (MDPI, 2023-05-12)
The Wilms tumor suppressor gene (Wt1) encodes a C2H2-type zinc-finger transcription factor that participates in transcriptional regulation, RNA metabolism, and protein–protein interactions. WT1 is involved in the development ... -
Del conocimiento
Muñoz-Chápuli-Oriol, Ramón (Universidad de Málaga, 2008)
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Dissecting the role of micro-RNA200B in epicardial-derived cell diversification and migration
Simón Fernández, S; Domínguez, JN; Vilches, JM; Hernández Torres, F; Ramírez Acuña, F; Carmona, R; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Muñoz-Chápuli-Oriol, Ramón; Franco, D; Aránega, AE[et al.] (2018-11-20)
Mostramos como miR200B se expresa en los estadios E12.5 y E15.5 durante el desarrollo cardiaco, en concreto en una subpoblación de células derivadas del epicardio. Experimentos de pérdida y ganancia de función muestran que ... -
El gen supresor del tumor de Wilms (Wt1) en el desarrollo, homeostasis y regeneración del páncreas
(UMA Editorial, 2020-02-17)Compuesta por cuatro publicaciones que se centran en tres aspectos fundamentales: 1) El papel de las células del epitelio celómico embrionario y por su derivado adulto, el mesotelio. Parece ser que ambos interaccionan con ... -
Expression of the Wilms tumor suppressor gene (Wt1) in a subpopulation of embryonic cardiomyocytes is required for cardiac development
Carmona-Mejías, Rita María; Cañete, Ana; Ariza Medina, Laura Maria; Torrado, Mario; Mikhailov, Alexander; Muñoz-Chápuli-Oriol, Ramón[et al.] (2017-02-06)
The Wilms’ tumour gene, WT1, encodes a zinc-finger transcription factor involved in the development of several organs. WT1 is expressed during mammalian embryonic development in many tissues, including the urogenital system, ... -
Functions of the Wilms' tumor suppressor gene (Wt1) in embryonic and adult myocardium
(UMA Editorial, 2023-06-15)The Wilms’ tumor suppressor gene (Wt1) is expressed in several cell types in the developing and adult heart, including epicardial and endothelial cells, fibroblasts and cardiomyocytes. Systemic Wt1 deletion causes the death ... -
La expresión miocárdica del gen supresor del tumor de Wilms (Wt1) es esencial para el desarrollo cardíaco y reaparece en cardiomiocitos adultos
Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; Guadix-Domínguez, Juan Antonio; Torrado, Mario; Mikhailov, Alexander; Pérez-Pomares, José María; Muñoz-Chápuli-Oriol, Ramón[et al.] (2017-12-18)
El gen supresor del tumor de Wilms, Wt1, codifica un factor de transcripción del tipo “dedos de zinc” implicado en transcripción, regulación post-transcripcional e interacciones proteína-proteína. La función de este gen ... -
La expresión miocárdica del gen supresor del tumor de Wilms(Wt1) es esencial para el desarrollo cardiaco
Muñoz-Chápuli-Oriol, Ramón; Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; Cañete, Ana; Torrado, Mario; Mikhailov, Alexander; Pérez-Pomares, José María[et al.] (2018-11-09)
El gen supresor del tumor de Wilms,Wt1, codifica un factor de transcripción del tipo “dedos de zinc” implicado en transcripción, regulación post-transcripcional e interacciones proteína-proteína. Durante el desarrollo ... -
Molecular evolution of nitric oxide synthases in metazoans.
Muñoz-Chápuli-Oriol, Ramón; González-Doménech, Carmen María (2010-08-09)
Nitric oxide synthases (NOS), the enzymes responsible for the NO synthesis, are present in all eukaryotes. Three isoforms (neuronal, inducible and endothelial), encoded by different loci, have been described in vertebrates, ... -
Proteomic data of murine hearts with conditional deletion of the gene Wt1
Díaz del Moral, Sandra; Muñoz-Chápuli-Oriol, Ramón; Carmona-Mejías, Rita María (Universidad de Málaga, 2022-11-10)
Este dataset contiene los resultados de una comparación de la proteómica de corazones de ratones con deleción condicional del gen Wt1 en el miocardio, tratados o no con doxorubicina, y sus correspondientes controles -
Raw data from the paper entitled "Deletion of the Wilms’ tumor suppressor gene in the cardiac troponin-T lineage reveals novel functions of WT1 in heart development"
Muñoz-Chápuli-Oriol, Ramón (Universidad de Málaga, 2021-06-14)
We performed a conditional ablation of Wt1 in the myocardium of mice embryos. RNASeq analysis identified differential expression of 137 genes in the E13.5 mutant heart as compared to controls. We provide raw data about the ... -
The evolutionary origins of chordate hematopoiesis and vertebrate endothelia
Pascual-Anaya, Juan; Albuixech-Crespo, Beatriz; Somorjai, Ildikó M. L.; Carmona-Mejías, Rita María; Oisi, Yasuhiro; Álvarez, Susana; Kuratani, Shigeru; Muñoz-Chápuli-Oriol, Ramón; Garcia-Fernàndez, Jordi[et al.] (Elsevier, 2013-03-15)
The vertebrate circulatory system is the most complex vascular system among those of metazoans, with key innovations including a multi-chambered heart and highly specialized blood cells. Invertebrate vessels, on the other ... -
The Wilms’ tumor suppressor gene is expressed in adult cardiomyocytes and it regulates myocardial metabolism and response to damage
Díaz del Moral, Sandra; Wagner, Kay-Dietrich; Wagner, Nicole; Benaouicha, Maha; Muñoz-Chápuli-Oriol, Ramón; Carmona-Mejías, Rita María[et al.] (2022-05)
The Wilms tumor suppressor gene (Wt1) encodes a C2H2-type zinc-finger transcription factor that participates in transcriptional regulation, RNA metabolism and protein-protein interactions. WT1 is critically involved in the ... -
Three embryonic cell lineages related with the epicardium show distinct developmental fates
Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; López Gambero, Antonio Jesús; Pérez-Pomares, José María; Muñoz-Chápuli-Oriol, Ramón (2018-11-09)
The embryonic epicardium generates a population of mesenchymal cells that contribute to the coronary vessels and the connective tissue of the adult heart. We have used murine cell-tracing models to compare the developmental ... -
Wt1 is involved in pancreas development and adult pancreatic homeostasis
Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; Aguilera, Beatriz; Cañete, Ana; Muñoz-Chápuli-Oriol, Ramón (2017-11-21)
The embryonic mesothelium lining the visceral organs gives rise to mesenchymal cells through a localized epithelial-mesenchymal transition (EMT). This has been extensively studied in some cases, such as the heart, where ...