• Dendrimers-modified solid supports: towards nanostructures materials for clinical diagnostic 

      Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; Montañe, M I; Perez-Inestrosa, E; [et al.] (2013-09-25)
      The design and synthesis of new materials for biomedical applications is a high-priority research topic in a number of biomedical areas. The rapid development of nanotechnology over the past few decades has created wide ...
    • Design and synthesis of new molecules based on indolium derivatives for two-photon absorption bioimaging applications 

      Benítez-Martín, Carlos; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2018-11-15)
      Bioimaging is the visualization of biological processes in real time, interfering as less as possible with these and using non-invasive methods. Among others, fluorescence methods have acquired a very important role in ...
    • Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition 

      Najera-Albendin, Francisco; Montañez, María Isabel; Ruiz-Sánchez, Antonio Jesús; Vida-Pol, Yolanda; Collado, Daniel; [et al.] (2014-06-12)
      Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ...
    • Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells 

      Najera-Albendin, Francisco; Benitez-Martin, Carlos; Guadix, Juan Antonio; Perez-Pomares, Jose Maria; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
      Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ...
    • Diseño y síntesis de nuevos dendrímeros 

      Morgado, Anjara; Molina, Noemi; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
      Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ...
    • Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular 

      Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2018-03-06)
      Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ...
    • Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas 

      Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
      Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ...
    • Energy transfer in Aminonaphthalimide-BODIPY dyads upon one and two photons excitation 

      Collado, Daniel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2014-07-03)
      BODIPY dyes are nowadays widely commercialized chromophores that have attracted immense interest as versatile tools in biological chemistry [1]. However, the generally very small Stokes shifts of BODIPY dyes may cause ...
    • Fijación de dendrímeros antigénicos en superficies para determinación de IgE 

      Vida-Pol, Yolanda; Montañez, María Isabel; Mesa, Pablo; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2016-02-15)
      Actualmente, el diseño de nuevos materiales con potenciales aplicaciones biomédicas es de gran importancia , sobre todo para su uso directo en diagnóstico clínico . En particular, los dispositivos que ...
    • Influencia de la Atropoisomería en la Organización Helicoidal de Organogeles en oligo-p-fenilenos 

      Nieto-Ortega, Belen; Aparicio, Fátima; Najera-Albendin, Francisco; Ramírez, Francisco Javier; López-Navarrete, Juan Teodomiro; [et al.] (Real Sociedad Española de Quimica, 2013-09-04)
    • Managing with (fluorescent)-biomimetic dendrimers 

      Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; Mesa-Antunez, Pablo; [et al.] (2017-06-30)
      Dendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more ...
    • New indolium fluorofores for two-photon absortion (2PA) bioimaging applications 

      Perez-Inestrosa, Ezequiel; Benitez, Carlos; Najera-Albendin, Francisco (2016)
      The development of organic materials with 2PA has attracted intensive attention in the past two decades [1]. In two-photon bio-imaging applications the design of the chromophore requires to have a good cross-section (σ2PA) ...
    • New molecules based indolium for two-photon absortion bioimaging applications 

      Benitez-Martin, Carlos; Pérez-Inestrosa, Ezequiel; Najera-Albendin, Francisco (Universidad de Extremadura, 2017)
      The development of organic materials with 2PA has attracted intensive attention in the past two decades. In two-photon bio-imaging applications the design of the chromophore requires to have a good cross-section and good ...
    • “Off-on” two-photon indolenine probes for pH bioimaging 

      Benítez-Martín, Carlos; Guadix, Juan A.; Pearson, John R.; Najera-Albendin, Francisco; Perez-Pomares, Jose Maria; [et al.] (2019-10-25)
      Fluorescence-based biosensors have become an indispensable tool in modern biology. These molecules can be used to monitor processes inside living cells and in real-time. The control of the pH is crucial in multiple biological ...
    • Preparation, photophysical properties and cell image of Naphthalimide-based fluorescent nanostructures for biomedical applications: BAPAD dendrimeric antigens and silica nanoparticles 

      Mesa, Pablo; Collado, Daniel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2014-07-17)
      We present here the synthesis and characterization of BAPAD [1] fluorescent Dendrimeric-Antigens (DeAn), to be applied in basophil activation as a test to detect drug allergy reactions. A second generation BAPAD dendrimer ...
    • RGD peptide on Dendrimer surfaces Affects Mesenchymal Stem Cells Adhesion 

      Vida-Pol, Yolanda; Molina, Noemi; Collado, Daniel; Najera-Albendin, Francisco; Lagunas, Anna; [et al.] (2016-04-07)
      Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ...
    • Sistema fluorescentes multifotónicos con aplicaciones en bioimagen 

      Collado, Daniel; Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Ramon, Patricia; [et al.] (2013-09-20)
      Los colorantes y las sondas fluorescentes son componentes clave en el estudio de muestras biológicas mediante microscopía de fluorescencia. Mientras que muchos colorantes fluorescentes disponibles comercialmente han sido ...
    • Syntehsis and use of dendrimeric structures as a tool in biomedicine 

      Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Najera-Albendin, Francisco (2019-10-28)
      Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ...
    • Synthesis and Biomedical aplications of BAPAD: Bisaminoalkylpolyamide Dendrimers 

      Perez-Inestrosa, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2014-02-06)
      A new class of Dendrimeric Systems (Dendrimers and Dendrons) and the study of their properties in molecular recognition processes are presented. These Dendrimers (BAPAD: BisAminoalkylPolyAmideDendrimers), are designed to ...
    • Synthesis of fluorescent BAPAD dendrimeric structrures for biomedical applications 

      Mesa-Antunez, Pablo; Collado, Daniel; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2014-02-03)
      In this work, we present the synthesis and characterization of BAPAD1 fluorescent Dendrimeric-Antigens (DeAn), to study the dendritic cell maturation as a test to detect drug allergy reactions. Recently our research group ...