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A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (2015-10-06)Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
Aggressive behavior of Merkel cell carcinoma of the skin may be related to tumor microvasculature density
Parrado-Romero, Concepcion; Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Narváez, José Ángel; [et al.] (2014-06-18)First primary MCC is a disease of elderly people. It is only sporadically reported before age 50; then, its overall age-adjusted incidence rate starts increasing gradually, from age 50 to age 65, then progressively in both ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon-Peñuela, Carmelo; Gago-Calderon, Belen; Flores-Burgess, Antonio; [et al.] (2017-08-30)Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Effects of galanin n-terminal fragment (1-15) in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Narváez, Manuel; Santin-Nuñez, Luis Javier; Narváez, José Ángel; [et al.] (2015-10-21)Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. The intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) and an ... -
Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations
Narváez, Manuel; Andrade-Talavera, Yuniesky; Fores-Pons, Ramon; Valladolid-Acebes, Ismael; Siegele, Pia; [et al.] (2021-11-04)The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant ... -
GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (2015-10-06)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
GALANIN (1-15) ENHANCEMENT OF THE BEHAVIORAL EFFECTS OF FLUOXETINE IN THE FORCED SWIMMING TEST GIVES A NEW THERAPEUTIC STRATEGY AGAINST DEPRESSION.
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Gago-Calderon, Belen; Narváez, Manuel; Borroto-Escuela, Dasiel; [et al.] (2017) -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Gago-Calderon, Belen; Narváez, Manuel; Borroto-Escuela, Dasiel O.; [et al.] (2017)The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ... -
Galanin (1-15) increased the neuropétide-Y Y1 receptor bindng in the amygdala of the rats
Flores-Burgess, Antonio; Díaz-Cabiale, Zaida; Millon-Peñuela, Carmelo; Narváez, Manuel; Narváez, José Ángel (2014-09-30)Galanin (GAL) and N-terminal Galanin fragment (1-15) [GAL(1-15)] interact at membrane level with Neuropeptide Y receptors. In the nucleus of the solitary tract GAL modified the cardiovascular action of the NPYY1 and GAL(1-15) ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (Cinp, 2016-07-03)Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque, Marina; Barbancho-Fernandez, Miguel Angel; López-Salas, Alexander; Alvarez-Contino, Jose Erik; García-Casares, Natalia; [et al.] (IOAP-MPDI, 2022-06-01)Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernandez, Miguel Angel; López-Salas, Alexander; Alvarez-Contino, Jose Erik; García-Casares, Natalia; [et al.] (2022-09-22)Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
Galanin and Neuropeptide Y interaction leads to antidepressant effects through hippocampal cell proliferation.
Narváez, Manuel; Fores-Pons, Ramón; Pita-Rodríguez, Mariana; Fuxe, Kjell; Borroto-Escuela, Dasiel (2020-09-01)Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide Y interactions linked to neuronal precursor cells of the dentate gyrus in the hippocampus. Role in depression and cognitive impairment.
Fores-Pons, Ramon; Borroto-Escuela, Dasiel O.; Pita-Rodriguez, Mariana; Barbancho-Fernandez, Miguel Angel; López-Salas, Alexander; [et al.] (2021-11-05)Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide y Y1 receptor agonist coinjection increases newborn cells proliferation on hippocampal dentate gyrus in rats
Narváez, Manuel; Borroto-Escuela, Dasiel O.; Santin-Nuñez, Luis Javier; Fuxe, Kjell (2018-07-13)The hippocampus is a region in which neurogenesis persists throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a ... -
Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderon, Belen; [et al.] (2015-10-05)We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderon, Belen; [et al.] (2016-07-11)We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (2016-07-27)Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
Millon-Peñuela, Carmelo; Narváez, Manuel; Flores-Burgess, Antonio; Parrado-Romero, Concepcion; Puigcerver-Martinez, Araceli; [et al.] (2014-07-16)Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have ... -
Galanin n-terminal fragment (1-15) induces an anxiety- and depressive-like behaviours in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Narváez, Manuel; Santin-Nuñez, Luis Javier; Narváez, José Ángel; [et al.] (2015-10-21)Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. We have shown that intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) ...